猫交感神经节中节前刺激或慢性去传入对神经降压素样免疫反应性的影响。

Effect of preganglionic stimulation or chronic decentralization on neurotensin-like immunoreactivity in sympathetic ganglia of the cat.

作者信息

Caverson M M, Bachoo M, Ciriello J, Polosa C

机构信息

Department of Physiology, McGill University, Montreal, Que., Canada.

出版信息

Brain Res. 1989 Mar 20;482(2):365-70. doi: 10.1016/0006-8993(89)91202-x.

DOI:10.1016/0006-8993(89)91202-x

PMID:2706494

Abstract

In pentobarbital-anesthetized cats, supramaximal stimulation (40 Hz, 2 h) of the preganglionic input to the acutely decentralized right stellate (RSG) or superior cervical (RSCG) ganglion resulted in a decrease in neurotensin (NT)-like immunoreactivity (IR), by 83% in the SG and by 46% in the SCG, as determined by radioimmunoassay. Chronic (7 days) decentralization of the ganglia resulted in a similar depletion of NT-like IR (SG: 86%; SCG: 76%). Supramaximal stimulation (40 Hz, 2 h) of the intact postganglionic outflow of either ganglion had no effect on NT-like IR. These data suggest that NT in the SG and SCG is present in preganglionic axons and is released by activation of these axons.

摘要

在戊巴比妥麻醉的猫中，对急性去中枢支配的右侧星状神经节（RSG）或颈上神经节（RSCG）的节前输入进行超强刺激（40Hz，2小时），通过放射免疫测定法测定，结果导致神经降压素（NT）样免疫反应性（IR）降低，在星状神经节中降低了83%，在颈上神经节中降低了46%。神经节的慢性（7天）去中枢支配导致类似的NT样IR耗竭（星状神经节：86%；颈上神经节：76%）。对任一神经节完整的节后传出纤维进行超强刺激（40Hz，2小时）对NT样IR没有影响。这些数据表明，星状神经节和颈上神经节中的NT存在于节前轴突中，并通过这些轴突的激活而释放。