头孢吡肟对肠杆菌科细菌的敏感剂量依赖性最低抑菌浓度对报告及处方的影响
Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing.
作者信息
Rivera Christina G, Narayanan Prasanna P, Patel Robin, Estes Lynn L
机构信息
Hospital Pharmacy Services, Mayo Clinic, Rochester, Minnesota, USA
Hospital Pharmacy Services, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Antimicrob Agents Chemother. 2016 May 23;60(6):3854-5. doi: 10.1128/AAC.00442-16. Print 2016 Jun.
The CLSI cefepime breakpoints were revised to include a susceptible-dose-dependent (SDD) category for Enterobacteriaceae, with the intention that higher cefepime doses be used for these isolates. In this study, 1.6% of Enterobacteriaceae isolates were reported as SDD, with Escherichia coli the most common SDD organism. Cefepime was prescribed in three cases (4.8%); the majority of SDD isolates were treated with a carbapenem. Enterobacteriaceae with cefepime SDD MICs were not commonly treated with cefepime at our institution.
临床和实验室标准协会（CLSI）修订了头孢吡肟的折点，为肠杆菌科细菌增加了剂量依赖敏感（SDD）类别，目的是对这些分离株使用更高剂量的头孢吡肟。在本研究中，1.6%的肠杆菌科分离株报告为SDD，其中大肠埃希菌是最常见的SDD菌。有3例（4.8%）使用了头孢吡肟；大多数SDD分离株使用碳青霉烯类进行治疗。在我们机构，头孢吡肟SDD最低抑菌浓度（MIC）的肠杆菌科细菌通常不使用头孢吡肟治疗。
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