Marsoner Katharina, Kornprat Peter, Sodeck Gottfried, Schagerl Jakob, Langeder Rainer, Csengeri Dora, Wagner Doris, Mischinger Hans Joerg, Haybaeck Johannes
Department of General Surgery, Medical University of Graz, Graz, Austria.
Department of General Surgery, Medical University of Graz, Graz, Austria
Anticancer Res. 2016 Apr;36(4):1979-84.
BACKGROUND/AIM: In this study we aimed to determine if advanced age represents a risk factor for negative perioperative and long-term outcome in patients undergoing curative surgery ductal pancreatic adenocarcinoma surgery.
Two-hundred-twenty-one consecutive patients, twelve (6%) patients ≥80 years were included in the study. We assessed perioperative and long-term outcome and independent predictors for in-hospital mortality with Cox regression analysis.
Advanced age was not a predictor for in-hospital mortality (6.3% in non-octogenarian versus 8.3% in octogenarians; p=0.55) nor for morbidity (31% vs. 32%; p=0.69). An ASA score >II was the only predictor for in-hospital mortality (odds ratio (OR)=10.10, 95%CI=1.28-79.60; Hosmer-Lemeshow: p=0.86). No significant difference was observed in one- and five-year survival rates (68 and 58% vs. 16 and 14%; log-rank p=0.61).
Advanced age is not a risk factor for negative outcome in curative pancreatic cancer surgery. Therefore, this single curative option should be considered in octogenarians at risk.
背景/目的：在本研究中，我们旨在确定高龄是否是接受根治性导管腺癌手术患者围手术期及长期不良预后的危险因素。
连续纳入221例患者，其中12例（6%）年龄≥80岁。我们评估了围手术期及长期预后，并通过Cox回归分析确定院内死亡的独立预测因素。
高龄并非院内死亡的预测因素（非八旬老人组为6.3%，八旬老人组为8.3%；p = 0.55），也不是发病的预测因素（分别为31%和32%；p = 0.69）。美国麻醉医师协会（ASA）评分>II是院内死亡的唯一预测因素（比值比（OR）= 10.10，95%置信区间= 1.28 - 79.60；Hosmer-Lemeshow检验：p = 0.86）。1年和5年生存率无显著差异（分别为68%和58% 对比16%和14%；对数秩检验p = 0.61）。
高龄并非根治性胰腺癌手术不良预后的危险因素。因此，对于有风险的八旬老人应考虑这一单一的根治性治疗选择。
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