Gao Yi-Qing, Gao Min, Xue Ying
Department of Endocrinology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
Exp Ther Med. 2016 Apr;11(4):1168-1172. doi: 10.3892/etm.2016.3039. Epub 2016 Jan 29.
Type 1 diabetes mellitus (T1D) and type 2 diabetes (T2D) mellitus are on the increase in children and adolescents. An increase in T2D is linked to the increasing rates of obesity in children. Usually, in both children and adults, T1D is treated with insulin while T2D is treated with metformin. There are other classes of drugs that are under assessment for their safety and efficacy in relation to pediatric patients. Most of these new drugs, however, have not been studied in children. Thus, the repertoire of drugs that are available to treat diabetes in children is limited. In this review, we outline the current pathology and treatment and future therapies of T1D mellitus and T2D mellitus in children.
1型糖尿病(T1D)和2型糖尿病(T2D)在儿童和青少年中的发病率正在上升。T2D的增加与儿童肥胖率的上升有关。通常,无论在儿童还是成人中,T1D用胰岛素治疗,而T2D用二甲双胍治疗。还有其他几类药物正在评估其对儿科患者的安全性和有效性。然而,这些新药大多尚未在儿童中进行研究。因此,可用于治疗儿童糖尿病的药物种类有限。在本综述中,我们概述了儿童T1D和T2D的当前病理、治疗方法及未来疗法。