近期大脑中动脉梗死区域内的新发胶质母细胞瘤与残留脑膜瘤：发病机制再探讨
De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited.
作者信息
Yaghmour Waseem, Kurdi Maher E, Baeesa Saleh S
机构信息
Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.
Department of Pathology, King Abdulaziz University, Jeddah, 21589, Kingdom of Saudi Arabia.
出版信息
World J Surg Oncol. 2016 Apr 18;14:112. doi: 10.1186/s12957-016-0876-7.
BACKGROUND
The pathogenesis of glioblastoma is complex, and the implicated molecular mechanisms are yet to be understood. There are scattered reports describing a possible relationship between meningioma and glioblastoma and more rarely a relationship between infarction and glioblastoma.
CASE PRESENTATION
We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma. He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma.
CONCLUSIONS
This case adds further contribution to the literature of the possible pathological association between glioblastoma and brain infarction on a background of meningioma.
背景
胶质母细胞瘤的发病机制复杂，其相关分子机制尚不清楚。有零散报道描述了脑膜瘤与胶质母细胞瘤之间可能存在的关系，而梗死与胶质母细胞瘤之间的关系则更为罕见。
病例介绍
我们报告一名32岁男性，因蝶骨脑膜瘤手术出现左大脑中动脉梗死这一手术并发症。4个月后，由于在先前大脑中动脉梗死区域和残留脑膜瘤附近发生胶质母细胞瘤，他出现了复发症状。
结论
该病例进一步丰富了关于在脑膜瘤背景下胶质母细胞瘤与脑梗死之间可能存在病理关联的文献。
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