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以色列十年间急性心肌梗死(AMI)时间趋势中的种族差异。索罗卡急性心肌梗死(SAMI-II)项目。

Ethnical disparities in temporal trends of acute myocardial infarction (AMI) throughout a decade in Israel. Soroka acute myocardial infarction (SAMI-II) project.

作者信息

Plakht Ygal, Gilutz Harel, Shiyovich Arthur

机构信息

Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

出版信息

Int J Cardiol. 2016 Jul 1;214:469-76. doi: 10.1016/j.ijcard.2016.04.009. Epub 2016 Apr 9.

Abstract

BACKGROUND

Ethnical disparities in presentation and outcomes following AMI were reported. We evaluated the temporal-trends of AMI hospitalizations and mortality of Bedouins (Muslims) and Jews in Israel.

METHODS

Retrospective analysis of 15,352 AMI admissions (10,652 patients; 11.3% Bedouins, 88.7% Jews) throughout 2002-2012. The trends in admission rates (AR) were compared using direct age-sex adjustment. The trends of in-hospital mortality (IHM) and 1-year post-discharge mortality (PDM) were adjusted for the patients' characteristics.

RESULTS

Bedouins were younger (61.7±14.3 vs. 68.8±13.7years, p<0.001), a higher rate of males. Different prevalence of cardiovascular risk factors was found. STEMI presentation, 3-vessel disease and PCI intervention were more frequently in Bedouins than Jews. Adjusted AR was lower among Jews (4.80/1000 and 3.24/1000 in 2002 and 2012 respectively) than in Bedouins (9.63/1000 and 5.13/1000). A significant decrease of adjusted AR was found in both ethnicities (p-for-trend<0.001 both), greater in Bedouins (p-for-disparity=0.017). The overall rate of IHM was higher for Jews (8.7% vs. 5.6%; p=0.001). The decline of IHM was found in both groups: an increase of one-year resulted in AdjOR=0.877; (p-for-trend<0.001) and 0.910 (p-for-trend=0.052) in Jews and Bedouins respectively (p-for-interaction=0.793). The rates of PDM were higher for Jews (13.6% vs. 9.9%; p=0.001). The risk for PDM increased in both groups: AdjOR=1.118; (p-for-trend<0.001) and 1.093; (p-for-trend=0.012) for one-year increase, for Jews and Bedouins respectively (p-for-interaction=0.927).

CONCLUSIONS

Throughout 2002-2012 Bedouin AMI patients differed from Jews. Adjusted incidence of AMI declined, greater in Bedouins. IHM declined and PDM increased in both groups. A culturally sensitive prevention program is warranted.

摘要

背景

有报道称急性心肌梗死(AMI)在发病表现和治疗结果方面存在种族差异。我们评估了以色列贝都因人(穆斯林)和犹太人急性心肌梗死住院治疗情况及死亡率的时间趋势。

方法

对2002年至2012年期间15352例急性心肌梗死入院病例(10652例患者;11.3%为贝都因人,88.7%为犹太人)进行回顾性分析。采用直接年龄-性别调整法比较入院率(AR)的趋势。对患者特征进行校正后分析住院死亡率(IHM)和出院后1年死亡率(PDM)的趋势。

结果

贝都因人更年轻(61.7±14.3岁 vs. 68.8±13.7岁,p<0.001),男性比例更高。发现心血管危险因素的患病率存在差异。ST段抬高型心肌梗死(STEMI)表现、三支血管病变和经皮冠状动脉介入治疗(PCI)在贝都因人中比犹太人更常见。校正后的入院率在犹太人中较低(2002年和2012年分别为4.80/1000和3.24/1000),低于贝都因人(9.63/1000和5.13/1000)。两个种族的校正入院率均显著下降(趋势p值均<0.001),贝都因人下降幅度更大(差异p值=0.017)。犹太人的总体住院死亡率更高(8.7% vs. 5.6%;p=0.001)。两组的住院死亡率均呈下降趋势:每增加一年,犹太人的调整后比值比(AdjOR)=0.877(趋势p值<0.001),贝都因人为0.910(趋势p值=0.052)(交互作用p值=0.793)。犹太人的出院后1年死亡率更高(13.6% vs. 9.9%;p=0.001)。两组出院后1年死亡率的风险均增加:每增加一年,犹太人的AdjOR=1.118(趋势p值<0.001),贝都因人为1.093(趋势p值=0.012)(交互作用p值=0.927)。

结论

在2002年至2012年期间,贝都因急性心肌梗死患者与犹太人不同。急性心肌梗死的校正发病率下降,贝都因人下降幅度更大。两组的住院死亡率均下降,出院后1年死亡率均上升。有必要开展具有文化敏感性的预防项目。

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