Meng Sisi, Guo Lijuan, Li Guangsen
Department of Ultrasound, Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China.
Department of Echocardiography, Liaoning Provincial People's Hospital, Shenyang, 110000, China.
Cardiovasc Ultrasound. 2016 Apr 19;14:16. doi: 10.1186/s12947-016-0058-3.
Heart ventricular dysfunction has been characterized as reduced longitudinal function of the right ventricle (RV), and is associated with chronic alcohol abuse. This study investigated the use of two-dimensional speckle tracking echocardiography (2DSTE) to assess the longitudinal systolic and diastolic RV function of patients with alcoholic myocardial damage.
We stratified 92 asymptomatic alcoholic men into three groups of increasing alcohol intake, Groups A-C. Thirty age-matched normal adult men served as the control group. Conventional echocardiography and tricuspid annulus peak systolic excursion (TAPSE) parameters were obtained. 2DSTE parameters were recorded from an apical 4-chamber view of the RV free wall. LV peak global longitudinal systolic strain was calculated from segmental averaging of the three apical long-axis views.
In Group C, the RV end diastolic diameter (RVEDD) was dramatically higher than that of Groups A, B and the control, while TAPSE was significantly lower in Group C compared with the other experimental groups. In Group B, the longitudinal early diastolic strain rate (SRe) and late diastolic strain rate (SRa) of the RV free wall, and LV longitudinal strain were significantly lower than that of Group A or the control. In Group C, all the 2DSTE parameters were significantly lower than that of the other groups. A significant negative linear correlation was noted between global RV systolic parameters systolic strain peak (S), peak systolic strain rate (SRs) and TAPSE (r1=-0.84, r2=-0.72, respectively, P <0.05).
Two-dimensional STE provided an effective and non-invasive method to assess the RV longitudinal function of patients with alcoholic myocardial damage. This methodology may be useful for diagnosing, directing treatment, and judging prognosis of alcoholic cardiac damage.
心室功能障碍的特征是右心室（RV）纵向功能降低，且与慢性酒精滥用有关。本研究调查了二维斑点追踪超声心动图（2DSTE）在评估酒精性心肌损伤患者右心室纵向收缩和舒张功能中的应用。
我们将92名无症状的男性酗酒者按酒精摄入量递增分为A - C三组。30名年龄匹配的正常成年男性作为对照组。获取常规超声心动图和三尖瓣环收缩期峰值位移（TAPSE）参数。从右心室游离壁的心尖四腔视图记录2DSTE参数。左心室整体纵向收缩期峰值应变通过三个心尖长轴视图的节段平均计算得出。
在C组中，右心室舒张末期直径（RVEDD）显著高于A组、B组和对照组，而C组的TAPSE与其他实验组相比显著降低。在B组中，右心室游离壁的纵向舒张早期应变率（SRe）和舒张晚期应变率（SRa）以及左心室纵向应变均显著低于A组或对照组。在C组中，所有2DSTE参数均显著低于其他组。右心室整体收缩期参数收缩期应变峰值（S）、收缩期峰值应变率（SRs）与TAPSE之间存在显著的负线性相关性（r1 = -0.84，r2 = -0.72，P <0.05）。
二维STE提供了一种有效且无创的方法来评估酒精性心肌损伤患者的右心室纵向功能。该方法可能有助于酒精性心脏损伤的诊断、指导治疗和判断预后。
