新型二苯醚类化合物的合成与抗病毒生物活性测定
Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds.
作者信息
Ibrahim Tarek S, Al-Mahmoudy Amany M M, Elagawany Mohamed, Ibrahim Mohamed A, Panda Siva S
机构信息
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, 22516, Egypt.
出版信息
Chem Biol Drug Des. 2016 Oct;88(4):511-8. doi: 10.1111/cbdd.12775. Epub 2016 May 27.
A set of diphenyl ether derivatives bearing different heterocycles were synthesized from 4-phenoxybenzohydrazide 1 in good yield. Synthesized compounds were screened against a broad panel of viruses in different cell cultures and some of the synthesized compounds showed promising antiviral properties.
以4-苯氧基苯甲酰肼1为原料，高产率地合成了一系列带有不同杂环的二苯醚衍生物。在不同细胞培养物中针对多种病毒对合成的化合物进行了筛选，部分合成化合物表现出了良好的抗病毒特性。
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