MTHFR和MTR基因多态性与俄罗斯族人群静脉曲张风险
Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians.
作者信息
Shadrina Alexandra Sergeevna, Sevost'ianova Kseniya Sergeevna, Shevela Andrey Ivanovich, Soldatsky Evgenii Yurievich, Seliverstov Evgenii Igorevich, Demekhova Marina Yurievna, Shonov Oleg Aleksandrovich, Ilyukhin Evgenii Arkadievich, Smetanina Mariya Aleksandrovna, Voronina Elena Nikolaevna, Pikalov Ilya Victorovich, Zolotukhin Igor Anatolyevich, Filipenko Maxim Leonidovich
机构信息
a Institute of Chemical Biology and Fundamental Medicine , Novosibirsk , Russia ;
b Novosibirsk State University , Novosibirsk , Russia ;
出版信息
Biomarkers. 2016 Nov;21(7):619-24. doi: 10.3109/1354750X.2016.1171902. Epub 2016 Apr 21.
OBJECTIVES
The objective of this study was to study the association of polymorphisms MTHFR C677T (rs1801133) and MTR A2756G (rs1805087) with the risk of varicose veins in ethnical Russians.
METHODS
We genotyped 475 patients with varicose veins, 168 individual without chronic venous disease, and the population-based group of 896 subjects. Association was studied using logistic regression analysis adopting co-dominant, additive, recessive, and dominant models of inheritance.
RESULTS
None of the polymorphisms showed a statistically significant association with the risk of varicose veins.
CONCLUSIONS
Our results provide evidence that the studied polymorphisms do not contribute to genetic susceptibility to varicose veins in ethnical Russians.
目的
本研究的目的是研究甲基四氢叶酸还原酶（MTHFR）C677T（rs1801133）和蛋氨酸合成酶还原酶（MTR）A2756G（rs1805087）基因多态性与俄罗斯族人群静脉曲张风险的相关性。
方法
我们对475例静脉曲张患者、168例无慢性静脉疾病的个体以及896名基于人群的受试者进行了基因分型。采用共显性、加性、隐性和显性遗传模型，通过逻辑回归分析研究相关性。
结果
这些多态性均未显示出与静脉曲张风险有统计学意义的相关性。
结论
我们的结果表明，所研究的基因多态性对俄罗斯族人群静脉曲张的遗传易感性没有影响。
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