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经皮长骨骨水泥成形术联合或不联合置入骨水泥填充导管治疗即将发生骨折的长骨转移痛的比较。

Comparison of percutaneous long bone cementoplasty with or without embedding a cement-filled catheter for painful long bone metastases with impending fracture.

机构信息

Department of Medical Imaging, Jinan Military General Hospital, No. 25 Shifan Road, Jinan, Shandong Province, 250031, China.

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Beijing, 100050, China.

出版信息

Eur Radiol. 2017 Jan;27(1):120-127. doi: 10.1007/s00330-016-4347-x. Epub 2016 Apr 21.

DOI:10.1007/s00330-016-4347-x
PMID:27097791
Abstract

OBJECTIVE

To compare the efficacy of percutaneous long bone cementoplasty (PLBC) with and without embedding a cement-filled catheter in the medullary canal (ECFC) for painful long bone metastases with impending fracture.

METHODS

A retrospective study was conducted in 36 consecutive patients undergoing PLBC and ECFC combination (n = 17, group A) or PLBC alone (n = 19, group B). All patients had a high risk of impending fracture in the long bone based on Mirels' scoring system. Clinical effects were evaluated using both a pre- and a postoperative visual analogue scale (VAS) and Karnofsky performance scale (KPS).

RESULTS

Overall pain relief rate with excellent (VAS 0-2) and good (VAS 2.5-4.5) results during follow-up was significantly higher in group A than in group B (88.2 % vs. 57.9 %, P<0.05). The average VAS and KPS changes in group A were significantly higher than those in group B at 1, 3 and 6 months postoperatively (P<0.05). Also, the rate of fractures of the treated long bone in group A was significantly lower than that in group B (P<0.05).

CONCLUSIONS

Combined PLBC and ECFC is a safe and effective procedure for long bone metastases with impending fracture.

KEY POINTS

• Metastases in long bones may cause pain and subsequent pathological fractures. • Cementoplasty resulted in significant pain relief in patients with long bone metastases. • Combination of PLBC and ECFC may reduce the incidence of fractures.

摘要

目的

比较经皮长骨骨水泥成形术(PLBC)联合和不联合髓腔中水泥填充导管(ECFC)治疗有骨折风险的疼痛性长骨转移瘤的疗效。

方法

回顾性分析 36 例接受 PLBC 和 ECFC 联合治疗(n = 17,A 组)或单纯 PLBC 治疗(n = 19,B 组)的连续患者。所有患者均根据 Mirels 评分系统存在长骨骨折高风险。采用术前和术后视觉模拟评分(VAS)和卡诺夫斯基表现量表(KPS)评估临床疗效。

结果

在随访期间,A 组的总疼痛缓解率(VAS 0-2 分和 VAS 2.5-4.5 分)明显高于 B 组(88.2%比 57.9%,P<0.05)。A 组在术后 1、3、6 个月时的平均 VAS 和 KPS 变化均明显高于 B 组(P<0.05)。此外,A 组治疗长骨骨折的发生率明显低于 B 组(P<0.05)。

结论

PLBC 联合 ECFC 是治疗有骨折风险的长骨转移瘤的一种安全有效的方法。

关键点

  1. 长骨转移瘤可能引起疼痛和随后的病理性骨折。

  2. 骨水泥成形术可显著缓解长骨转移瘤患者的疼痛。

  3. PLBC 联合 ECFC 可降低骨折发生率。

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