Liu WangMi, Jiang Libo, Bian Chong, Liang Yun, Xing Rong, Yishakea Mumingjiang, Dong Jian
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Arch Immunol Ther Exp (Warsz). 2016 Oct;64(5):371-83. doi: 10.1007/s00005-016-0395-9. Epub 2016 Apr 20.
Chemokines are a family of small 8-10 kDa inducible cytokines. Initially characterized as chemotactic factors, they are now considered to affect not just cellular recruitment. CX3CL1 is a unique chemokine that can exist in a soluble form, as a chemotactic cytokine, or in a membrane-attached form that acts as a binding molecule. Recently, the effects of CX3CL1 on diseases, such as inflammation and cancer, have been supported and confirmed by numerous publications. However, due to its dual effects, CX3CL1 exerts numerous effects on pathophysiological conditions that have both negative and positive consequences on pathogenesis and outcome. This review article summarizes the important scientific and clinical data that now point to a critical role for CX3CL1 in diseases.
趋化因子是一类分子量为8 - 10 kDa的可诱导小分子细胞因子。最初被表征为趋化因子，现在认为它们不仅影响细胞募集。CX3CL1是一种独特的趋化因子，它可以以可溶性形式作为趋化细胞因子存在，也可以以膜附着形式作为结合分子存在。最近，众多出版物支持并证实了CX3CL1对炎症和癌症等疾病的影响。然而，由于其双重作用，CX3CL1对病理生理状况产生了许多影响，这些影响对发病机制和结果既有负面的也有正面的。这篇综述文章总结了重要的科学和临床数据，这些数据现在表明CX3CL1在疾病中起关键作用。
