细菌对抗生素肽的耐药性：一种不断演变的现象。

Bacterial resistance to antimicrobial peptides: an evolving phenomenon.

机构信息

Pos-Graduacao da Faculdade de Medicina, Campus Universitario Darcy Ribeiro, Universidade de Brasilia, Asa Norte, Brasília, DF, Brazil and S-Inova, Programa de Pos-Graduacao em Biotecnologia, Universidade Catolica Dom Bosco, 79117-900 Campo Grande, MS, Br.

S-Inova, Programa de Pos-Graduacao em Biotecnologia, Universidade Catolica Dom Bosco, 79117-900 Campo Grande, MS, Brazil and Department of Biochemistry, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast.

出版信息

Front Biosci (Landmark Ed). 2016 Jun 1;21(5):1013-38. doi: 10.2741/4438.

DOI:10.2741/4438

PMID:27100488

Abstract

Bacterial resistance to conventional antibiotics is currently a real problem all over the world, making novel antimicrobial compounds a real research priority. Some of the most promising compounds found to date are antimicrobial peptides (AMPs). The benefits of these drugs include their broad spectrum of activity that affects several microbial processes, making the emergence of resistance less likely. However, bacterial resistance to AMPs is an evolving phenomenon that compromises the therapeutic potential of these compounds. Therefore, it is mandatory to understand bacterial mechanisms of resistance to AMPs in depth, in order to develop more powerful AMPs that overcome the bacterial resistance response.

摘要

目前，细菌对传统抗生素的耐药性是全世界面临的一个真正问题，这使得新型抗菌化合物成为真正的研究重点。迄今为止发现的最有前途的化合物之一是抗菌肽 (AMPs)。这些药物的好处包括它们广泛的作用谱，影响几种微生物过程，从而降低了产生耐药性的可能性。然而，细菌对 AMP 的耐药性是一个不断发展的现象，这损害了这些化合物的治疗潜力。因此，深入了解细菌对 AMP 的耐药机制是必要的，以便开发出更有效的 AMP 来克服细菌的耐药反应。