Girolomoni G, Mattina R, Manfredini S, Vertuani S, Fabrizi G
Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy.
Department of Biomedical Science for Health, University of Milan, Milan, Italy.
Int J Clin Pract. 2016 May;70 Suppl 184:4-13. doi: 10.1111/ijcp.12808.
Bacterial infections of the skin and soft tissues are frequent disorders. They can be primitive infections (e.g. impetigo, folliculitis) or secondary infections complicating other diseases, particularly atopic dermatitis. The most common aetiologic agent is Staphylococcus aureus. Topical antibiotic therapy may be sufficient in many instances to control these infections. Fusidic acid is an antibiotic used topically on the skin which is very active against S. aureus, including methicillin-resistant strains, and other Gram-positive bacteria. Resistance rates to fusidic acid are stably low. A fusidic acid and betamethasone formulation in a lipid-enriched cream (lipid cream) has been recently developed in order to provide effective antibacterial and anti-inflammatory activities in conjunction with a powerful emollient and moisturising effect. This preparation may be especially useful in patients with atopic-infected eczema.
皮肤和软组织的细菌感染是常见疾病。它们可以是原发性感染(如脓疱病、毛囊炎)或继发于其他疾病的感染,尤其是特应性皮炎。最常见的病原体是金黄色葡萄球菌。在许多情况下,局部抗生素治疗足以控制这些感染。夫西地酸是一种用于皮肤局部的抗生素,对金黄色葡萄球菌(包括耐甲氧西林菌株)和其他革兰氏阳性菌非常有效。对夫西地酸的耐药率一直很低。最近开发了一种含有夫西地酸和倍他米松的富含脂质的乳膏(脂质乳膏),以便在具有强大润肤和保湿作用的同时提供有效的抗菌和抗炎活性。这种制剂对患有特应性感染性湿疹的患者可能特别有用。