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[铁在心力衰竭中重要吗?]

[Is iron important in heart failure?].

作者信息

Murín Ján, Pernický Miroslav

出版信息

Vnitr Lek. 2015 Dec;61(12 Suppl 5):5S50-5.

Abstract

Iron deficiency is a frequent comorbidity in a patient with chronic heart failure, and it associates with a worse prognosis of that patient. Mainly worse quality of life and more rehospitalizations are in these iron deficient patients. Iron metabolism is rather complex and there is some new information concerning this complexity in heart failure. We distinquish an absolute and a functional iron deficiency in heart failure. It is this deficit which is important and not as much is anemia important here. Prevalence of anaemia in heart failure is about 30-50%, higher it is in patients suffering more frequently heart failure decompensations. Treatment of iron deficiency is important and it improves prognosis of these patients. Most experiences there are with i.v. iron treatment (FERRIC HF, FAIR HF and CONFIRM HF studies), less so with per oral treatment. There are no clinical trials which analysed mortality influences.

摘要

缺铁是慢性心力衰竭患者常见的合并症,且与患者预后较差相关。这些缺铁患者主要生活质量较差且再次住院更为频繁。铁代谢相当复杂,关于心力衰竭中这种复杂性有一些新信息。我们区分心力衰竭中的绝对缺铁和功能性缺铁。正是这种缺乏很重要,而在此处贫血的重要性相对没那么大。心力衰竭中贫血的患病率约为30% - 50%,在更频繁发生心力衰竭失代偿的患者中更高。缺铁的治疗很重要,它能改善这些患者的预后。大多数经验来自静脉铁剂治疗(FERRIC HF、FAIR HF和CONFIRM HF研究),口服治疗的经验较少。尚无分析死亡率影响的临床试验。

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