弥散张量成像在杜氏肌营养不良症中的研究。
Diffusion tensor imaging study in Duchenne muscular dystrophy.
机构信息
1 Department of Neurology, 2 Department of MRI, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China ; 3 Department of Neurology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing 100005, China.
出版信息
Ann Transl Med. 2016 Mar;4(6):109. doi: 10.21037/atm.2016.03.19.
BACKGROUND
Duchenne muscular dystrophy (DMD) is a progressive muscle disorder associated with an intellectual deficit which is non-progressive. The aim of this study was to investigate brain microstructural changes in DMD and to explore the relationship between such changes and cognitive impairment.
METHODS
All participants (12 DMD patients, 14 age-matched healthy boys), intelligence quotients (IQs) [both full (FIQ) and verbal (VIQ)] were evaluated using the Wechsler intelligence scale for children China revised (WISC-CR) edition, and brain gray matter (GM) and white matter (WM) changes were mapped using diffusion tensor imaging (DTI) with fractional anisotropy (FA). The differences between groups were analyzed using the t-test and the association of cognition with neuroimaging parameters was evaluated using Pearson's correlation coefficient.
RESULTS
Compared to the normal controls, the DMD group had lower FIQ (82.0±15.39 vs. 120.21±16.06) and significantly lower splenium of corpus callosum (CC) FA values (P<0.05). Splenium of CC FA was positively correlated with VIQ (r=0.588, P=0.044).
CONCLUSIONS
There were microstructural changes of splenium of CC in DMD patients, which was associated with cognitive impairment.
背景
杜氏肌营养不良症（DMD）是一种进行性肌肉疾病，伴有非进行性智力缺陷。本研究旨在探讨 DMD 患者的脑微观结构变化，并探讨这些变化与认知障碍之间的关系。
方法
所有参与者（12 名 DMD 患者，14 名年龄匹配的健康男孩）均采用中国修订韦氏儿童智力量表（WISC-CR）版评估智商（FIQ 和 VIQ），并用弥散张量成像（DTI）测量脑灰质（GM）和白质（WM）变化的各向异性分数（FA）。采用 t 检验比较组间差异，采用 Pearson 相关系数评估认知与神经影像学参数的相关性。
结果
与正常对照组相比，DMD 组的 FIQ 较低（82.0±15.39 比 120.21±16.06），胼胝体压部 FA 值明显较低（P<0.05）。胼胝体压部 FA 值与 VIQ 呈正相关（r=0.588，P=0.044）。
结论
DMD 患者胼胝体压部存在微观结构变化，与认知障碍有关。
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