Matcuk George R, Siddiqi Imran, Cen Steven, Hagiya Ashley, Isaacson Reese, Brynes Russell
Department of Radiology, Keck School of Medicine, University of Southern California.
Department of Pathology, Keck School of Medicine, University of Southern California.
Clin Imaging. 2016 May-Jun;40(3):392-7. doi: 10.1016/j.clinimag.2015.11.018. Epub 2015 Dec 2.
To calculate bone marrow cellularity from MRI and correlate with bone marrow biopsy.
Twenty-seven lymphoma patients with staging bone marrow biopsies and lumbar MRI were reviewed. Cellularity was calculated from T1 signal intensity measurements=100 - {[(marrow - CSF)/(subcutaneous fat - CSF)] X 100}.
The histologic cellularities demonstrated significant correlation with iliac bone MRI cellularity (r=0.59, P=.001). Cellularities increased from T11 to S1. Cellularity decreased with age=67.6 - (age X 0.36).
Marrow cellularity from MRI shows statistically significant correlation with biopsy and significant differences between vertebral levels and changes with age.
通过磁共振成像（MRI）计算骨髓细胞密度，并与骨髓活检结果进行相关性分析。
回顾性分析27例经分期骨髓活检及腰椎MRI检查的淋巴瘤患者。细胞密度通过T1信号强度测量值计算得出：细胞密度=100 - {[(骨髓信号强度-脑脊液信号强度)/(皮下脂肪信号强度-脑脊液信号强度)]×100}。
组织学细胞密度与髂骨MRI细胞密度呈显著相关性（r=0.59，P=0.001）。细胞密度从胸11至骶1逐渐增加。细胞密度随年龄增长而降低，计算公式为：细胞密度=67.6 - （年龄×0.36）。
MRI测量的骨髓细胞密度与活检结果具有统计学显著相关性，且在不同椎体水平存在显著差异，并随年龄变化。
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