人工角膜植入术后感染。
Infections after keratoprosthesis.
作者信息
Davies Emma, Chodosh James
机构信息
Cornea and External Disease Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Curr Opin Ophthalmol. 2016 Jul;27(4):373-7. doi: 10.1097/ICU.0000000000000270.
PURPOSE OF REVIEW
The purpose is to provide an overview of the recent advancements in the diagnosis and treatment of microbial keratitis and endophthalmitis after keratoprosthesis implantation.
RECENT FINDINGS
The addition of vancomycin daily to a fluoroquinolone in the postoperative management of keratoprosthesis patients successfully reduced the number of cases of bacterial keratitis and endophthalmitis with an increased number of fungal infections now documented both in the United States and abroad.
SUMMARY
Compliance with the regimen of a fluoroquinolone and vancomycin daily for life after keratoprosthesis implantation should be stressed with the patient. Further research is needed to investigate whether intermittent use of 5% povidone-iodine and frequent replacement of the bandage contact lens could reduce fungal infection after keratoprosthesis surgery. Future advancements in the Boston keratoprosthesis design and/or postoperative management are needed to further reduce infection after keratoprosthesis placement.
综述目的
本文旨在概述角膜移植术后微生物性角膜炎和眼内炎诊断与治疗的最新进展。
最新发现
在美国和国外，目前均有文献记载，在角膜移植患者的术后管理中，每日在氟喹诺酮类药物基础上加用万古霉素，成功减少了细菌性角膜炎和眼内炎的病例数，但真菌感染病例数有所增加。
总结
应向患者强调角膜移植术后需终身每日坚持使用氟喹诺酮类药物和万古霉素的治疗方案。还需进一步研究间歇性使用5%聚维酮碘和频繁更换绷带式隐形眼镜是否可减少角膜移植术后的真菌感染。未来需要在波士顿角膜移植的设计和/或术后管理方面取得进展，以进一步减少角膜移植术后的感染。
Zotero 插件