Sanders Kiah L, Fox Barbara A, Bzik David J
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon, NH, USA.
Oncoimmunology. 2015 Oct 29;5(4):e1104447. doi: 10.1080/2162402X.2015.1104447. eCollection 2016 Apr.
We have recently reported that treatment of disseminated pancreatic cancer with an attenuated uracil auxotroph vaccine promoted antitumor CD8 T cell responses and long-term survival. Here, we optimized the treatment strategy for disseminated pancreatic cancer and show that attenuated therapy stimulated effective long-term immunity to pancreatic cancer through mechanisms involving CD4 T cells and pancreatic tumor-specific IgG. Our results suggest that cell-mediated immunity in conjunction with humoral antibody immunity may offer greater resistance to recurrence of highly aggressive tumors. Cancer immunotherapeutic strategies using attenuated vaccines merit further investigation as a novel strategy to reawaken immunity to primary pancreatic carcinoma and to generate long-lasting immunity to pancreatic cancer recurrences.
我们最近报道,用减毒的尿嘧啶营养缺陷型疫苗治疗播散性胰腺癌可促进抗肿瘤CD8 T细胞反应并延长生存期。在此,我们优化了播散性胰腺癌的治疗策略,并表明减毒疗法通过涉及CD4 T细胞和胰腺肿瘤特异性IgG的机制刺激了对胰腺癌的有效长期免疫。我们的结果表明,细胞介导的免疫与体液抗体免疫相结合可能对高侵袭性肿瘤的复发提供更大的抵抗力。使用减毒疫苗的癌症免疫治疗策略作为一种重新唤醒对原发性胰腺癌的免疫并产生对胰腺癌复发的持久免疫的新策略值得进一步研究。