Murthy Raghav, Sebastian Vinod A, Huang Rong, Guleserian Kristine J, Forbess Joseph M
Department of Cardiovascular Surgery, Rady Children's Hospital, San Diego, CA, USA
Division of Pediatric Cardiothoracic Surgery, Cook Children's Hospital, Fort Worth, TX, USA.
World J Pediatr Congenit Heart Surg. 2016 May;7(3):329-33. doi: 10.1177/2150135115625203.
The single ventricle reconstruction trial showed better one-year transplant-free survival for the right ventricle-to-pulmonary artery (RV-to-PA) conduit over the modified Blalock-Taussig shunt (mBTS) at Norwood operation. However, concerns remain about the long-term effects of a neonatal ventriculotomy. In our institution, we have used specific selection criteria for the use of mBTS in the Norwood operation.
We reviewed 122 consecutive neonates undergoing the Norwood procedure from December 2006 to December 2013. We used the following criteria to select our source of pulmonary blood flow: (1) presence of a dominant morphologic left ventricle; (2) presence of antegrade blood in an ascending aorta that is greater than 3 mm; and (3) presence of significant large "crossing coronaries" on ventricle. All patients who met any of the above 3 criteria underwent an mBTS while the remaining patients underwent an RV-to-PA conduit.
Seventy-five (61.5%) patients had the RV-to-PA conduit and 47 (38.5%) patients had an mBTS. The overall surgical mortality was 9%. Mean follow-up interval was 23.5 months. Actuarial transplant-free survival was similar at 12, 24, 36, and 48 months in both the mBTS group and the RV-to-PA conduit group. In the RV-to-PA conduit group, actuarial transplant-free survival was 73% at 12 months, 71% at 24 months, 71% at 36 months, and 67% at 48 months, while in the mBTS group, actuarial transplant-free survival was 82% at 12 months, 75% at 24 months, 75% at 36 months, and 75% at 48 months.
Our selection criteria for mBTS have allowed us to obtain equivalent transplant-free survival at 12, 24, 36, and 48 months when compared to the RV-to-PA conduit group.
单心室重建试验表明,在诺伍德手术中,右心室至肺动脉(RV-to-PA)导管的一年无移植生存率优于改良布莱洛克-陶西格分流术(mBTS)。然而,新生儿心室切开术的长期影响仍令人担忧。在我们机构,我们在诺伍德手术中使用mBTS时采用了特定的选择标准。
我们回顾了2006年12月至2013年12月期间连续接受诺伍德手术的122例新生儿。我们使用以下标准来选择肺血流来源:(1)存在占优势的形态学左心室;(2)升主动脉中存在大于3毫米的顺行血流;(3)心室上存在明显的大“交叉冠状动脉”。所有符合上述3条标准中任何一条的患者均接受mBTS,其余患者接受RV-to-PA导管。
75例(61.5%)患者接受了RV-to-PA导管,47例(38.5%)患者接受了mBTS。总体手术死亡率为9%。平均随访间隔为23.5个月。mBTS组和RV-to-PA导管组在12、24、36和48个月时的无移植生存率相似。在RV-to-PA导管组中,12个月时的无移植生存率为73%,24个月时为71%,36个月时为71%,48个月时为67%,而在mBTS组中,12个月时的无移植生存率为82%,24个月时为75%,36个月时为75%,48个月时为75%。
我们的mBTS选择标准使我们在12、24、36和48个月时获得了与RV-to-PA导管组相当的无移植生存率。