囊性纤维化中新获得的铜绿假单胞菌分离株根除失败
Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis.
作者信息
Cohen-Cymberknoh Malena, Gilead Noa, Gartner Silvia, Rovira Sandra, Blau Hannah, Mussaffi Huda, Rivlin Joseph, Gur Michal, Shteinberg Michal, Bentur Lea, Livnat Galit, Aviram Micha, Picard Elie, Tenenbaum Ariel, Armoni Shoshana, Breuer Oded, Shoseyov David, Kerem Eitan
机构信息
CF Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Medical School, Hebrew University, Jerusalem, Israel.
出版信息
J Cyst Fibros. 2016 Nov;15(6):776-782. doi: 10.1016/j.jcf.2016.04.006. Epub 2016 May 1.
UNLABELLED
Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients.
OBJECTIVES
To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure.
METHODS
In an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥1year.
RESULTS
Of 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken.
CONCLUSIONS
Delayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.
未标注
根除铜绿假单胞菌（PA）对囊性纤维化（CF）患者至关重要。
目的
确定新获得的PA的根除成功率，并识别与根除失败相关的特征。
方法
在一项观察性研究中，收集了2007年至2013年新获得PA感染患者的数据。对根除成功≥1年和未成功根除的患者的临床变量进行了比较。
结果
来自7个CF中心的740例患者中有183例（25%）新获得PA，其中72%根除成功。失败风险最高的患者有多耐药PA、痰培养次数较少、年龄较大且诊断时年龄较晚。CF诊断每延迟一年，根除失败风险增加1.3%；每增加一次痰培养，成功根除率增加17%。
结论
PA感染检测延迟导致治疗延迟和多耐药菌生长与根除失败有关。
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