Bussell R M, Nichol R, Toumba K J
Department of Child Dental Health, School of Dentistry, University of Leeds, Clarendon Way, Leeds, LS2 9LU, UK.
Doncaster Community Dental Service, The Flying Scotsman Centre, St Sepulchre Gate West, Doncaster, DN1 3AP, UK.
Eur Arch Paediatr Dent. 2016 Jun;17(3):177-85. doi: 10.1007/s40368-016-0226-z. Epub 2016 May 4.
To provide a comprehensive report of fluoride concentration in UK infant milks and estimate their contribution to daily fluoride intake.
A total of 60 formula milk products available commercially or within a hospital environment were analysed, along with eight pasteurised cow's milk samples. Formula milk products requiring preparation were reconstituted with fresh Leeds tap water (0.02 ppmF). Fluoride concentration was measured for all products directly using an ion selective electrode after addition of low-level total ionic strength adjustment buffer.
The overall median fluoride concentration for the 68 infant milks was 0.025 ppmF, with a wide range of 0.002-0.282 ppmF. Analysis revealed variation between composition and manufacturer, in addition to differences between measured and labeled fluoride concentration. Although all products contained low fluoride concentration, the fluoride concentrations for formula milks used within the hospital setting (0.029 ppmF) were statistically higher in comparison to the commercial formula milk (0.016 ppmF) and cow's milk (0.017 ppmF) products. The daily fluoride contribution from infant milks was low; 0.0034 mgF/kg body weight per day was estimated between birth and 6 months of age, further decreasing as intake of infant milk decreased with age.
Fluoride concentration of the analysed infant milks is low, providing minimal contribution towards total daily F intake and alone are unlikely to pose a threat for the development of dental fluorosis.
提供一份关于英国婴儿奶粉中氟化物浓度的综合报告,并估算其对每日氟摄入量的贡献。
共分析了60种市售或医院环境中可得的配方奶粉产品,以及8份巴氏杀菌牛奶样本。需要调配的配方奶粉产品用新鲜的利兹自来水(0.02 ppmF)复溶。在添加低水平总离子强度调节缓冲液后,直接使用离子选择电极测量所有产品的氟化物浓度。
68种婴儿奶粉的总体氟化物浓度中位数为0.025 ppmF,范围为0.002 - 0.282 ppmF。分析显示,除了测量的氟化物浓度与标签标注的浓度存在差异外,成分和制造商之间也存在差异。尽管所有产品的氟化物浓度都较低,但医院环境中使用的配方奶粉的氟化物浓度(0.029 ppmF)与市售配方奶粉(0.016 ppmF)和牛奶(0.017 ppmF)产品相比,在统计学上更高。婴儿奶粉对每日氟摄入量的贡献较低;估计出生至6个月龄期间,每日每千克体重的氟摄入量为0.0034 mgF,随着婴儿奶粉摄入量随年龄增长而减少,这一数值会进一步降低。
所分析的婴儿奶粉中氟化物浓度较低,对每日总氟摄入量的贡献极小,单独食用不太可能对氟斑牙的发展构成威胁。