Matsuzuka Takashi, Suzuki Masahiro, Saijoh Satoshi, Ikeda Masakazu, Imaizumi Mitsumasa, Nomoto Yukio, Matsui Takamichi, Tada Yasuhiro, Omori Koichi
Nihon Jibiinkoka Gakkai Kaiho. 2016 Feb;119(2):125-8. doi: 10.3950/jibiinkoka.119.125.
We retrospectively analyzed 54 patients who died of head and neck squamous cell caricinoma regarding the process and duration of cachexia using the modified Glasgow Prognostic Score (mGPS). The patients were classified as having cachexia when the serum albumin level was less than 3.5 mg/dL and the C-reactive protein (CRP) level was more than 0.5 mg/dL. The number of patients with cachexia was eight (8%) at the first visit and 50 (93%) at the time of death. In the 50 patients, the median and average time of having cachexia was 59 and 95 days, respectively. Thirty-two of the 50 patients (64%) died within three months after the presence of cachexia was confirmed. In this study, the time of having cachexia was so short, then the policy of care should be converted from aggressive into supportive in patients classified as having cachexia. mGPS would be an accurate assessment tool for cachexia and ascertain the end stage of head and neck cancer patients.
我们使用改良格拉斯哥预后评分(mGPS)对54例死于头颈部鳞状细胞癌的患者的恶病质进程和持续时间进行了回顾性分析。当血清白蛋白水平低于3.5mg/dL且C反应蛋白(CRP)水平高于0.5mg/dL时,患者被归类为患有恶病质。初诊时患有恶病质的患者有8例(8%),死亡时为50例(93%)。在这50例患者中,出现恶病质的中位时间和平均时间分别为59天和95天。50例患者中有32例(64%)在恶病质确诊后三个月内死亡。在本研究中,出现恶病质的时间如此之短,因此对于被归类为患有恶病质的患者,护理策略应从积极治疗转变为支持治疗。mGPS将是一种用于评估恶病质的准确工具,并可确定头颈部癌症患者的终末期。