Vesenbeckh Silvan, Krieger David, Bettermann Gudrun, Schönfeld Nicolas, Bauer Torsten Thomas, Rüssmann Holger, Mauch Harald
Department of Pneumology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Walterhöfer Str 11, 14165 Berlin, Germany.
Institute of Microbiology, HELIOS Klinikum Emil von Behring, Walterhöfer Str 11, 14165 Berlin, Germany.
Tuberculosis (Edinb). 2016 May;98:27-9. doi: 10.1016/j.tube.2016.02.003. Epub 2016 Feb 26.
Due to an increase of drug resistant TB, alternative drugs that are not currently listed in the WHO guidelines on MDR TB treatment are currently being evaluated. Our group tested 100 susceptible, 20 MDR and 2 XDR Mtb strains against the phenothiazine derivatives thioridazine, trifluoperazine and triflupromazine. MIC testing was performed on Middlebrook 7H10 agar and was defined as the lowest drug concentration that inhibits ≥99% of the bacterial population. We confirm very good in vitro activity of phenothiazines against Mycobacterium tuberculosis. In >77% of all strains MICs of ≤10 μg/ml were found.
由于耐多药结核病的增加，目前正在评估世界卫生组织耐多药结核病治疗指南中未列出的替代药物。我们的团队针对吩噻嗪衍生物硫利达嗪、三氟拉嗪和三氟丙嗪，测试了100株敏感、20株耐多药和2株广泛耐药结核分枝杆菌菌株。在Middlebrook 7H10琼脂上进行最低抑菌浓度（MIC）测试，MIC被定义为抑制≥99%细菌群体的最低药物浓度。我们证实吩噻嗪类药物对结核分枝杆菌具有非常好的体外活性。在所有菌株中，>77%的菌株MIC≤10μg/ml。
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