正电子发射断层扫描（PET）在小儿脑发育及发育障碍评估中的应用
PET in the Assessment of Pediatric Brain Development and Developmental Disorders.
作者信息
Kumar Ajay, Chugani Harry T
机构信息
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA.
Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA; Division of Pediatric Neurology, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, USA; PET Center, Children's Hospital of Michigan, Detroit, MI 48201, USA.
出版信息
PET Clin. 2008 Oct;3(4):487-515. doi: 10.1016/j.cpet.2009.04.006. Epub 2009 Jul 25.
This article discusses and reviews the role and contribution of PET in understanding the structural and functional changes that occur during brain development, and how these changes relate to behavioral and cognitive development in the infant and child. Data regarding various aspects of brain development, such as glucose metabolism, protein synthesis, and maturation and development of neurotransmitter systems will help in understanding the pathogenesis and neurologic basis of various developmental and neurologic disorders. This may help in following disease evolution and progression, planning and development of various therapeutic interventions, timing these interventions and monitoring their responses, and rendering long-term prognostication.
本文探讨并综述了正电子发射断层扫描（PET）在理解大脑发育过程中发生的结构和功能变化方面的作用及贡献，以及这些变化如何与婴幼儿的行为和认知发展相关。关于大脑发育各个方面的数据，如葡萄糖代谢、蛋白质合成以及神经递质系统的成熟与发育，将有助于理解各种发育和神经疾病的发病机制及神经学基础。这可能有助于跟踪疾病的演变和进展，规划和开展各种治疗干预措施，确定这些干预措施的时机并监测其反应，以及进行长期预后评估。
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