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用于淋巴瘤治疗的新型正电子发射断层显像(PET)放射性示踪剂

Novel PET Radiotracers for Potential Use in Management of Lymphoma.

作者信息

Kostakoglu Lale

机构信息

Division of Nuclear Medicine, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

出版信息

PET Clin. 2012 Jan;7(1):83-117. doi: 10.1016/j.cpet.2011.12.002.

Abstract

This article discusses possible roles for emerging novel positron emission tomography (PET) radiotracers for diagnosis and follow-up of lymphomas. Novel imaging probes are being developed to fulfill the need of a more specific radiopharmaceutical to target subcomponents of tumor microenvironment to individualize management approaches. Noninvasive molecular imaging probes are being developed to revolutionize characterization of tumor biology and response to therapy in more specific ways for the host, tumor microenvironment, and therapeutic regimens. The new clinical PET probes seem promising in fostering clinical gains that would lead to better survival outcomes, although further studies are warranted to prove a role in the management of lymphomas.

摘要

本文讨论了新兴的新型正电子发射断层扫描(PET)放射性示踪剂在淋巴瘤诊断和随访中的可能作用。正在开发新型成像探针,以满足对更具特异性的放射性药物的需求,该药物可靶向肿瘤微环境的亚成分,从而实现个体化治疗方案。正在开发非侵入性分子成像探针,以更具体地针对宿主、肿瘤微环境和治疗方案,彻底改变肿瘤生物学特征及对治疗反应的表征。尽管还需要进一步研究来证明其在淋巴瘤治疗中的作用,但新的临床PET探针似乎有望带来临床获益,从而改善生存结果。

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