Raffan Eleanor, Dennis Rowena J, O'Donovan Conor J, Becker Julia M, Scott Robert A, Smith Stephen P, Withers David J, Wood Claire J, Conci Elena, Clements Dylan N, Summers Kim M, German Alexander J, Mellersh Cathryn S, Arendt Maja L, Iyemere Valentine P, Withers Elaine, Söder Josefin, Wernersson Sara, Andersson Göran, Lindblad-Toh Kerstin, Yeo Giles S H, O'Rahilly Stephen
University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Cell Metab. 2016 May 10;23(5):893-900. doi: 10.1016/j.cmet.2016.04.012. Epub 2016 May 3.
Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.
对拉布拉多寻回犬肥胖候选基因进行测序时，发现促肾上腺皮质激素原（POMC）中有一个14bp的缺失，等位基因频率为12%。该缺失破坏了β-促黑素和β-内啡肽的编码序列，并与体重（每个等位基因效应为0.33标准差）、肥胖和更强的食物动机有关。在其他犬种中，该缺失仅在亲缘关系密切的平毛寻回犬（FCR）中发现，在FCR中它同样与体重和食物动机有关。在被选作辅助犬的拉布拉多寻回犬中，该突变比宠物拉布拉多寻回犬更为常见。总之，POMC中的缺失是拉布拉多寻回犬和平毛寻回犬体重和食欲的重要调节因子，可能还会影响其他行为特征。
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