用于脑肿瘤临床监测和治疗反应评估的PET参数反应映射
PET Parametric Response Mapping for Clinical Monitoring and Treatment Response Evaluation in Brain Tumors.
作者信息
Ellingson Benjamin M, Chen Wei, Harris Robert J, Pope Whitney B, Lai Albert, Nghiemphu Phioanh L, Czernin Johannes, Phelps Michael E, Cloughesy Timothy F
机构信息
Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Biomedical Physics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Biomedical Engineering, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
出版信息
PET Clin. 2013 Apr;8(2):201-17. doi: 10.1016/j.cpet.2012.09.002. Epub 2012 Oct 23.
PET parametric response maps (PRMs) are a provocative new molecular imaging technique for quantifying brain tumor response to therapy in individual patients. By aligning sequential PET scans over time using anatomic MR imaging information, the voxel-wise change in radiotracer uptake can be quantified and visualized. PET PRMs can be performed before and after a particular therapy to test whether the tumor is responding favorably, or performed relative to a distant time point to monitor changes through the course of a treatment. This article focuses on many of the technical details involved in generating, visualizing, and quantifying PET PRMs, and practical applications and example case studies.
正电子发射断层扫描（PET）参数反应图谱（PRMs）是一种用于量化个体患者脑肿瘤治疗反应的新型分子成像技术，颇具启发性。通过利用解剖磁共振成像信息对不同时间的PET扫描进行配准，可以对放射性示踪剂摄取的体素级变化进行量化和可视化。PET PRMs可在特定治疗前后进行，以检测肿瘤是否有良好反应，也可相对于较远的时间点进行，以监测整个治疗过程中的变化。本文重点介绍了生成、可视化和量化PET PRMs所涉及的许多技术细节，以及实际应用和实例研究。
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