脂质运载蛋白2水平升高可能在真性红细胞增多症和原发性血小板增多症患者的血栓形成事件中起重要作用。
Increased Lipocalin 2 level may have important role in thrombotic events in patients with polycythemia vera and essential thrombocythemia.
作者信息
Rajnics P, Kellner Á, Karádi É, Moizs M, Bödör Cs, Király P A, Marosvári D, Andrikovics H, Egyed M
机构信息
Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
出版信息
Leuk Res. 2016 Sep;48:101-6. doi: 10.1016/j.leukres.2016.04.016. Epub 2016 Apr 28.
The aim of our study was to evaluate the possible effect of lipocalin 2 on thrombotic events in polycythemia vera and essential thrombocythemia patients. The samples of 89 patients were collected and RNA based method was used to evaluate the relative gene expression level of lipocalin 2. 74 samples were available for evaluation. Drawing a cut off point at level 30 relative expression rate, 13 patients with elevated lipocalin 2 expression had thrombotic events during the course of their disease. Based on these data high lipocalin 2 expression level seems to have strong positive predictive value on thrombotic events in patients with polycythemia vera and essential thrombocythemia. Lipocalin 2 may be useful in thrombotic risk stratification in these patients.
我们研究的目的是评估脂质运载蛋白2对真性红细胞增多症和原发性血小板增多症患者血栓形成事件的可能影响。收集了89例患者的样本，并采用基于RNA的方法评估脂质运载蛋白2的相对基因表达水平。有74个样本可供评估。以相对表达率30为分界点，13例脂质运载蛋白2表达升高的患者在病程中发生了血栓形成事件。基于这些数据，脂质运载蛋白2的高表达水平似乎对真性红细胞增多症和原发性血小板增多症患者的血栓形成事件具有很强的阳性预测价值。脂质运载蛋白2可能有助于这些患者的血栓形成风险分层。
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