费城染色体阳性急性淋巴细胞白血病或淋巴母细胞危象期慢性髓性白血病

Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia or Chronic Myeloid Leukemia in Lymphoid Blast Crisis.

作者信息

Kolenova Alexandra, Maloney Kelly W, Hunger Stephen P

机构信息

*Department of Pediatric Hematology and Oncology, Comenius University Medical School and University Children's Hospital, Bratislava, Slovak Republic †Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO ‡Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

出版信息

J Pediatr Hematol Oncol. 2016 Aug;38(6):e193-5. doi: 10.1097/MPH.0000000000000582.

DOI:10.1097/MPH.0000000000000582

PMID:27164534

Abstract

The clinical characteristics of chronic myeloid leukemia (CML) in lymphoid blast crisis (BC) can resemble those of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL). Because of this, there can be concern as to whether a patient with newly diagnosed Ph leukemia has Ph ALL or CML in lymphoid BC. This distinction has significant potential therapeutic implications because most children with Ph ALL are now treated with chemotherapy plus a tyrosine kinase inhibitor, whereas allogeneic stem cell transplant is usually recommended for any patient with CML that presents in or later develops BC.

摘要

慢性髓性白血病（CML）处于淋巴细胞母细胞危象（BC）时的临床特征可能类似于费城染色体阳性急性淋巴细胞白血病（Ph ALL）。因此，对于新诊断的Ph白血病患者是患Ph ALL还是处于淋巴细胞BC期的CML可能会存在疑问。这种区分具有重要的潜在治疗意义，因为现在大多数Ph ALL儿童患者接受化疗加酪氨酸激酶抑制剂治疗，而对于任何处于或后来发展为BC期的CML患者，通常建议进行异基因干细胞移植。