质子泵抑制剂加速内皮细胞衰老。
Proton Pump Inhibitors Accelerate Endothelial Senescence.
作者信息
Yepuri Gautham, Sukhovershin Roman, Nazari-Shafti Timo Z, Petrascheck Michael, Ghebre Yohannes T, Cooke John P
机构信息
From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
出版信息
Circ Res. 2016 Jun 10;118(12):e36-42. doi: 10.1161/CIRCRESAHA.116.308807. Epub 2016 May 10.
RATIONALE
Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.
OBJECTIVE
To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction.
METHODS AND RESULTS
Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.
CONCLUSIONS
Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.
理论依据
质子泵抑制剂（PPIs）是治疗胃食管反流的常用药物，目前无需医疗监督即可长期使用。最近的报告表明，使用PPIs与心血管、肾脏和神经疾病有关。
目的
研究PPIs对内皮功能障碍和衰老的长期影响，并探讨PPIs诱导血管功能障碍的机制。
方法与结果
长期接触PPIs会损害内皮功能，并通过缩短端粒长度加速人内皮细胞衰老。
结论
我们的数据可能为使用PPIs与心血管、肾脏和神经疾病及死亡风险增加之间的关联提供一个统一的机制。
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