Vos G D, Wiegman A, Romijn J A, Meurs A M, Bruins-Stassen M J, Bijlmer R P, van Lieshout J J
Ned Tijdschr Geneeskd. 1989 Apr 15;133(15):772-5.
The symptoms and clinical course of meningococcaemia in 14 cases are described; 10 patients died; in one of the four survivors amputations were inevitable for necrosis of hands and feet. The foremost symptoms at the first time that a doctor was contacted were fever, lethargy, petechiae and purpura. The fulminant course is shown by the high number of resuscitation at the time of admission or in the first hours after admission, and by the time between first symptoms and death. The mortality of meningococcaemia is mostly not due to meningitis. Most patients die of septic shock even before signs of meningitis can develop. The early signs of meningococcaemia are not those of meningitis, but those of sepsis. Meningism and headache are rare symptoms. The severest symptoms are fever and lethargy, in combination with petechiae and purpura. The fulminant course of the disease requires immediate admission. Treatment of infection and septic shock may be lifesaving.
本文描述了14例脑膜炎球菌血症的症状和临床病程;10例患者死亡;4名幸存者中有1人因手脚坏死而不可避免地进行了截肢。首次联系医生时最主要的症状是发热、嗜睡、瘀点和紫癜。暴发性病程表现为入院时或入院后最初几小时内大量需要复苏的情况,以及首次出现症状到死亡的时间间隔。脑膜炎球菌血症的死亡率大多并非由于脑膜炎。大多数患者甚至在脑膜炎症状出现之前就死于感染性休克。脑膜炎球菌血症的早期症状不是脑膜炎的症状,而是败血症的症状。颈项强直和头痛是罕见症状。最严重的症状是发热、嗜睡,伴有瘀点和紫癜。该病的暴发性病程需要立即入院。感染和感染性休克的治疗可能挽救生命。