去铁胺在放射性骨牵张成骨中的临床应用
Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone.
作者信息
Momeni Arash, Rapp Scott, Donneys Alexis, Buchman Steven R, Wan Derrick C
机构信息
*Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford, CA †Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
出版信息
J Craniofac Surg. 2016 Jun;27(4):880-2. doi: 10.1097/SCS.0000000000002633.
The deleterious effects of radiotherapy, including hypovascularity and hypocellularity, have made distraction of irradiated bones challenging. Animal studies, however, have demonstrated adjunctive measures such as the administration of deferoxamine to significantly improve bone regeneration across irradiated distraction gaps. In this report, the authors demonstrate, for the first time, enhanced bone formation following deferoxamine application in a patient following distraction of a previously irradiated maxilla. Computed tomography imaging of the pterygomaxillary buttress on the side of administration revealed significantly increased bone area and density relative to the contralateral buttress. This is the first presentation of clinical deferoxamine use to promote bone formation following irradiated bone distraction and highlights the promise for this adjunctive measure to make outcomes after distraction of irradiated bone more reliable.
放疗的有害影响，包括血管减少和细胞减少，使得对受照射骨骼进行牵张成骨具有挑战性。然而，动物研究表明，诸如给予去铁胺等辅助措施可显著改善受照射牵张间隙处的骨再生。在本报告中，作者首次证明了在一名先前接受过照射的上颌骨牵张成骨患者中应用去铁胺后骨形成增强。对给药侧翼上颌支柱进行的计算机断层扫描成像显示，相对于对侧支柱，骨面积和骨密度显著增加。这是首次展示临床使用去铁胺促进受照射骨牵张成骨后的骨形成，并突出了这种辅助措施有望使受照射骨牵张成骨后的结果更可靠。
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