Beltrán Ramírez O, Mendoza Rincón J F, Barbosa Cobos R E, Alemán Ávila I, Ramírez Bello J
Research Unit in Endocrine and Metabolic Diseases, Hospital Juárez de México, Mexico City, Mexico.
Laboratorio de Oncología Molecular, Unidad de Diferenciación Celular y Cáncer, FES-Zaragoza, UNAM, Mexico City, Mexico.
Immunol Lett. 2016 Jul;175:40-3. doi: 10.1016/j.imlet.2016.05.003. Epub 2016 May 10.
STAT4 has been consistently associated with several autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The aim of this study was to determine whether the STAT4 rs7574865G/T polymorphism confers susceptibility for RA and SLE in a sample of Mexican patients. This study included 869 individuals: 415 patients with RA, 128 patients with SLE, and 326 controls. Genotyping using TaqMan probes showed an association between the STAT4 rs7574865G/T polymorphism and RA (GG vs. TT: OR 1.99, p=0.0009; G vs. T: OR 1.42, p=0.0009) and SLE (GG vs. TT: OR 2.98, 0.0003; G vs. T: OR 1.74, p=0.0002). Gender stratification showed an association with RA (GG vs. TT: OR 1.99, 95% CI 1.3-3.1, p=0.002; G vs. T: OR 1.42, 95% CI 1.1-1.8, p=0.002) and SLE (GG vs. TT: OR 3.3, 95% CI 1.7-6.2, p=0.0002; G vs. T: OR 1.8, 95% CI 1.3-2.4, p=0.0002) in women. Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population.
信号转导和转录激活因子4（STAT4）一直与多种自身免疫性疾病相关，包括类风湿性关节炎（RA）和系统性红斑狼疮（SLE）。本研究的目的是确定STAT4基因rs7574865G/T多态性是否会使墨西哥患者样本易患RA和SLE。本研究纳入了869名个体：415例RA患者、128例SLE患者和326名对照。使用TaqMan探针进行基因分型显示，STAT4基因rs7574865G/T多态性与RA（GG与TT：比值比1.99，p = 0.0009；G与T：比值比1.42，p = 0.0009）和SLE（GG与TT：比值比2.98，p = 0.0003；G与T：比值比1.74，p = 0.0002）有关。按性别分层显示，该多态性与女性的RA（GG与TT：比值比1.99，95%置信区间1.3 - 3.1，p = 0.002；G与T：比值比1.42，95%置信区间1.1 - 1.8，p = 0.002）和SLE（GG与TT：比值比3.3，95%置信区间1.7 - 6.2，p = 0.0002；G与T：比值比1.8，95%置信区间1.3 - 2.4，p = 0.0002）有关。因此，STAT4基因rs7574865G/T多态性会使墨西哥人群患RA和SLE的风险增加。
