额叶血清素2A受体结合水平低是精神分裂症的一种状态标志物吗？
Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?
作者信息
Rasmussen Hans, Frokjaer Vibe G, Hilker Rikke W, Madsen Jacob, Anhøj Simon, Oranje Bob, Pinborg Lars H, Glenthøj Birte, Knudsen Gitte M
机构信息
Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Psychiatric Center Glostrup, Copenhagen University Hospital Glostrup, Denmark.
Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, University of Copenhagen, Denmark.
出版信息
Eur Neuropsychopharmacol. 2016 Jul;26(7):1248-50. doi: 10.1016/j.euroneuro.2016.04.008. Epub 2016 May 11.
Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.
在此，我们对一组极为罕见的精神分裂症同卵双胞胎进行了成像，他们在血清素2A受体（5-HT2AR）结合方面存在差异，以深入了解大脑5-HT2AR模式中的特质和状态成分。在四对未服用靶向5-HT2AR药物的双胞胎中，与健康的双胞胎相比，精神分裂症患者额叶的5-HT2AR结合始终较低（33%）。我们的结果强烈表明额叶5-HT2AR可用性低是精神分裂症的一种状态特征。如果能在更大的样本中重复这一结果，理想情况下样本还包括异卵双胞胎和未服用过药物的患者，这一发现将极大地推进我们对精神分裂症复杂病理生理学的理解。
Zotero 插件