通过EndoPAT方法证明子痫前期患者存在内皮功能障碍和动脉僵硬度增加。
Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method.
作者信息
Meeme A, Buga G A, Mammen M, Namugowa A
机构信息
Department of Human Biology, Walter Sisulu University, Mthatha, South Africa. Email:
Department of Obstetrics and Gynaecology, Walter Sisulu University, Mthatha, South Africa.
出版信息
Cardiovasc J Afr. 2017;28(1):23-29. doi: 10.5830/CVJA-2016-047. Epub 2016 May 19.
OBJECTIVES
The EndoPAT method has been used as a non-invasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia.
METHODS
Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine.
RESULTS
The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001).
CONCLUSION
The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.
目的
EndoPAT方法已被用作评估多种非妊娠人群内皮功能的一种非侵入性方法。我们研究了其在评估子痫前期内皮功能障碍方面的潜在用途。
方法
招募了215名参与者，分为子痫前期病例组（105例）和血压正常对照组（110例）。使用EndoPAT 2000机器分别将反应性充血指数和增强指数作为内皮功能和动脉僵硬度进行测量。
结果
与血压正常组相比，子痫前期组的反应性充血指数显著降低（p < 0.05）。另一方面，与血压正常组相比，子痫前期组的增强指数显著升高（p < 0.0001）。
结论
EndoPAT方法证实了子痫前期存在内皮功能障碍和动脉僵硬度。
Zotero 插件