Yoshikane Frances, Lai Li Han, Hui Brian K, Martins Deborah B, Farias-Eisner Gina, Mandelbaum Rachel S, Hoang Han, Bradley James P, Wilson Libby, Lee Justine C
Division of Plastic and Reconstructive Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, Calif.; Division of Plastic and Reconstructive Surgery, Temple University, Philadelphia, Pa.; and Craniofacial/Cleft Palate Program, Orthopaedic Hospital, Los Angeles, Calif.
Plast Reconstr Surg Glob Open. 2016 Apr 7;4(4):e676. doi: 10.1097/GOX.0000000000000656. eCollection 2016 Apr.
Understanding long-term sequelae of cleft treatment is paramount in the refinement of treatment algorithms to accomplish optimized immediate and long-term outcomes. In this study, we reviewed sphincter pharyngoplasties as a method of velopharyngeal insufficiency (VPI) treatment in relationship to orthognathic surgery.
Cleft lip/palate and cleft palate patients, 15 years of age and older, were reviewed for demographics, VPI surgery, revisions, and subsequent orthognathic surgery at 2 institutions. Chi-square test, Student's t test, and logistic regression analyses were performed.
In 214 patients reviewed (mean age, 19.5 years), 61.7% were male, 18.2% had isolated cleft palate, 61.2% had unilateral cleft lip and palate, and 20.6% had bilateral cleft lip and palate. A total of 33.6% were diagnosed with VPI and received a sphincter pharyngoplasty (mean age, 11.9 years). When subsequent orthognathic surgery was examined, sphincter pharyngoplasty was not associated with maxillary advancement (P = 0.59) but did correlate with an increase in mandibular surgery from 2.8% to 11.1% (P = 0.02). The indications for mandibular surgery in the pharyngoplasty population were related to congenital micrognathia. When cephalometric analyses were evaluated, sphincter pharyngoplasty resulted in a decreased sella-to-nasion-to-B point angle (mean, 79.0-76.3 degrees, P = 0.02) and a higher incidence of normal to class II maxillomandibular relationships as defined by A point-to-nasion-to-B point angles >0.5 (P = 0.02).
Sphincter pharyngoplasty decreases anterior mandibular growth and the discrepancy between maxillomandibular skeletal relationships because of the frequent predisposition of cleft patients to maxillary hypoplasia. In patients with congenital mandibular micrognathia, a small increase in mandibular surgeries may occur.
了解腭裂治疗的长期后遗症对于完善治疗方案以实现优化的近期和远期疗效至关重要。在本研究中,我们回顾了咽括约肌成形术作为腭咽闭合不全(VPI)治疗方法与正颌外科手术的关系。
对两家机构中15岁及以上的唇腭裂和腭裂患者进行人口统计学、VPI手术、修复手术及后续正颌外科手术的回顾。进行了卡方检验、学生t检验和逻辑回归分析。
在回顾的214例患者(平均年龄19.5岁)中,61.7%为男性,18.2%为单纯腭裂,61.2%为单侧唇腭裂,20.6%为双侧唇腭裂。共有33.6%被诊断为VPI并接受了咽括约肌成形术(平均年龄11.9岁)。在检查后续正颌外科手术时,咽括约肌成形术与上颌前移无关(P = 0.59),但与下颌手术从2.8%增加到11.1%相关(P = 0.02)。咽成形术人群中下颌手术的指征与先天性小颌畸形有关。当评估头影测量分析时,咽括约肌成形术导致蝶鞍-鼻根- B点角减小(平均,79.0 - 76.3度,P = 0.02),并且A点-鼻根- B点角>0.5定义的正常至II类上颌下颌关系的发生率更高(P = 0.02)。
由于腭裂患者常易出现上颌发育不全,咽括约肌成形术会降低下颌前部生长以及上颌下颌骨骼关系之间的差异。在先天性下颌小颌畸形患者中,下颌手术可能会有小幅增加。