1型糖尿病患者中脂蛋白相关磷脂酶A2在脂蛋白之间的分布存在差异。
Lipoprotein-associated phospholipase A2 distribution among lipoproteins differs in type 1 diabetes.
作者信息
Jarvie Jennifer L, Wang Hong, Kinney Gregory L, Snell-Bergeon Janet, Hokanson John E, Eckel Robert H
机构信息
Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Barbara Davis Center for Childhood Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
出版信息
J Clin Lipidol. 2016 May-Jun;10(3):577-86. doi: 10.1016/j.jacl.2016.01.001. Epub 2016 Jan 30.
BACKGROUND
LpPLA2 mass and activity have been variably related to cardiovascular disease risk, and the distribution of LpPLA2 in patients with type 1 diabetes (T1D), wherein cardiovascular disease risk is high despite normal or higher levels of high-density lipoprotein (HDL) cholesterol, is unknown.
OBJECTIVE
To determine whether there are differences in the distribution of LpPLA2 mass and activity across lipoproteins and their association with coronary artery calcium (CAC) in patients with T1D.
METHODS
Men with T1D (n = 19) not on statins, with and without CAC progression, and men without diabetes matched for HDL cholesterol (n = 25) had lipoproteins separated by fast protein liquid chromatography.
RESULTS
Both LpPLA2 mass and activity were found within low-density lipoprotein (LDL) and HDL pools with more LpPLA2 mass being associated with HDL (54% vs 44%; P-value <.001) and more LpPLA2 activity being associated with LDL (56% vs 40%; P value = .02). In T1D, more LpPLA2 activity was associated with large- or less-dense LDL compared to those without diabetes. However, no difference in LpPLA2 activity or mass between lipoprotein subfractions was observed between all groups, and there was no relationship between LpPLA2 activity or mass and its distribution and CAC score progression in healthy or T1D men.
CONCLUSION
LpPLA2 is found in both LDL and HDL and is distributed differently in men with T1D without any relationship to CAC score progression.
背景
脂蛋白相关磷脂酶A2（LpPLA2）的质量和活性与心血管疾病风险的关系存在差异，1型糖尿病（T1D）患者的心血管疾病风险较高，尽管其高密度脂蛋白（HDL）胆固醇水平正常或较高，但LpPLA2在这些患者中的分布情况尚不清楚。
目的
确定T1D患者中LpPLA2质量和活性在脂蛋白中的分布差异及其与冠状动脉钙化（CAC）的关联。
方法
未服用他汀类药物、有或无CAC进展的T1D男性患者（n = 19）以及HDL胆固醇匹配的非糖尿病男性患者（n = 25），通过快速蛋白质液相色谱法分离脂蛋白。
结果
在低密度脂蛋白（LDL）和HDL组分中均发现了LpPLA2的质量和活性，更多的LpPLA2质量与HDL相关（54%对44%；P值<.001），更多的LpPLA2活性与LDL相关（56%对40%；P值 =.02）。与非糖尿病患者相比，T1D患者中更多的LpPLA2活性与大颗粒或低密度LDL相关。然而，所有组之间脂蛋白亚组分的LpPLA2活性或质量均未观察到差异，并且在健康男性或T1D男性中，LpPLA2活性或质量及其分布与CAC评分进展之间没有关系。
结论
LpPLA2存在于LDL和HDL中，在T1D男性中的分布不同，但与CAC评分进展无任何关系。
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