Riaz Hafiza Fizzah, Mannan Shaheen, Malik Sajid
Department of Animal Sciences, Human Genetics Program, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
J Health Popul Nutr. 2016 May 20;35:14. doi: 10.1186/s41043-016-0049-x.
Rahim Yar Khan (RYK) District is a multi-ethnic assemblage of both ancient and migrated communities in Southern Punjab, Pakistan. There is a paucity of knowledge on the bio-demographic structure of this endogamous population.
We have carried out a cross-sectional epidemiological study in RYK District and recruited 2174 random Muslim married females. Detailed account of marital union types, level of consanguinity, and subject's fertility, was taken.
The analyses of these data revealed that consanguineous unions (CU) were 58.46 %, rendering an inbreeding coefficient (IC-F) = 0.0355. The CU were observed to be significantly higher in subjects originating from rural areas, speaking Saraiki language, illiterate or having a religious/Madarsa education only, and belonging to nuclear family type. The rate of consanguinity was also higher in subjects whose husbands were engaged in unskilled manual or skilled manual jobs, and had consanguinity in the parental generation. Multivariate logistic regression analyses revealed that variables like Saraiki language, illiteracy, reciprocal marriages, and parental consanguinity, were the significant predictors of CU in the subject. Among the first cousin unions (which constituted 52 % of all marriages), parallel-cousin and patrilineal unions were in the majority (54 and 57 %, respectively), and father's brother's daughter type had the highest representation (31 %). The analyses further demonstrated that fertility and mean live-births were significantly higher in women who had CU compared to the non-consanguineous (NCU) group (p < 0.006); and significantly higher number of sons per women were born to the mothers who had CU compared with the NCU sample (p = 0.0002). However, there were no differences in the CU and NCU samples with respect to pre- or post-natal mortalities and child morbidities.
The scientific findings in RYK District are distinct from the observations in other Pakistani populations and clue to a unique nature of this population. This study presents a comprehensive account of consanguinity and IC-F in RYK District and would be helpful in getting an insight into the structure of this population.
拉希姆亚尔汗（RYK）地区是巴基斯坦旁遮普省南部一个由古老和迁徙社区组成的多民族聚居地。关于这个近亲通婚群体的生物人口结构，我们所知甚少。
我们在RYK地区开展了一项横断面流行病学研究，随机招募了2174名已婚穆斯林女性。详细记录了婚姻结合类型、近亲结婚程度以及受试者的生育情况。
对这些数据的分析显示，近亲婚姻（CU）占58.46%，近亲繁殖系数（IC-F）=0.0355。在来自农村地区、说萨拉基语、文盲或仅接受宗教/宗教学校教育、属于核心家庭类型的受试者中，近亲婚姻的比例明显更高。在丈夫从事非技术体力劳动或技术体力劳动且父母一代有近亲关系的受试者中，近亲结婚率也更高。多因素逻辑回归分析显示，诸如萨拉基语、文盲、相互通婚和父母近亲关系等变量是受试者近亲婚姻的重要预测因素。在所有婚姻中占52%的表亲婚姻中，平行表亲婚姻和父系婚姻占多数（分别为54%和57%），父亲兄弟的女儿类型占比最高（31%）。分析进一步表明，与非近亲婚姻（NCU）组相比，有近亲婚姻的女性的生育率和平均活产数显著更高（p<0.006）；与NCU样本相比，有近亲婚姻的母亲所生儿子的数量显著更多（p=0.0002）。然而，在产前或产后死亡率以及儿童发病率方面，CU组和NCU组没有差异。
RYK地区的科学研究结果与其他巴基斯坦人群的观察结果不同，这表明了该人群的独特性质。本研究全面阐述了RYK地区的近亲关系和IC-F，将有助于深入了解该人群的结构。
