表观遗传学修饰：食物过敏的发病机制和生物标志物。
Epigenetic modifications: mechanisms of disease and biomarkers of food allergy.
机构信息
Murdoch Childrens Research Institute, The University of Melbourne Department of Paediatrics, Royal Children's Hospital, Melbourne, Australia; The University of Melbourne, Department of Paediatrics, Australia; Telethon Institute for Child Health Research, Australia; University of Western Australia, Department of Paediatrics, Australia; IN-FLAME International Inflammation Network, Australia.
Murdoch Childrens Research Institute, The University of Melbourne Department of Paediatrics, Royal Children's Hospital, Melbourne, Australia; The University of Melbourne, Department of Paediatrics, Australia.
出版信息
Curr Opin Immunol. 2016 Oct;42:9-15. doi: 10.1016/j.coi.2016.05.005. Epub 2016 May 21.
The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways. High-throughput methylation profiling of immune cell subtypes or whole blood from patients allows the identification of disease specific epigenetic variants. If faithfully tracking with disease parameters, these 'signatures' may have clinical applications as biomarkers of disease or therapeutic response. Development of such tools will depend on a number of factors, including determining the most appropriate experimental approach, analysis methodology, patient groups, and informative target cells/tissues. Here we discuss these potential applications and their implications for food allergy practise.
近年来 IgE 介导的食物过敏的增加可能是通过表观遗传途径介导的基因-环境相互作用的结果。由于表观遗传修饰，包括 DNA 甲基化，处于环境和基因组之间的界面，因此它们可能是可修改疾病途径的理想生物标志物。对患者的免疫细胞亚型或全血进行高通量甲基化谱分析可识别疾病特异性表观遗传变异。如果与疾病参数忠实地跟踪，这些“特征”可能具有作为疾病或治疗反应的生物标志物的临床应用。此类工具的开发将取决于多个因素，包括确定最合适的实验方法、分析方法、患者群体和信息丰富的靶细胞/组织。在这里，我们讨论了这些潜在的应用及其对食物过敏实践的意义。
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