Saglani Sejal, Fleming Louise
a Inflammation, Repair and Development , National Heart & Lung Institute, Imperial College London , London , UK.
b Respiratory Paediatrics , Royal Brompton Hospital , London , UK.
Expert Rev Respir Med. 2016 Aug;10(8):873-9. doi: 10.1080/17476348.2016.1191355. Epub 2016 Jun 2.
Children with difficult asthma have significant morbidity and fail to achieve asthma control despite being prescribed high dose maintenance treatment. If control remains poor after diagnostic confirmation, detailed assessments of the reasons for asthma being difficult-to-control are needed. Underlying modifiable factors including non-adherence to medication, persistent environmental exposures that trigger asthma symptoms and psychosocial factors contribute to poor control in these patients.
The focus of this review is to provide a practical approach to the diagnosis and management of difficult asthma including an overview of long term assessments to identify potential progression to true, severe asthma. A multi-disciplinary team is critical to enable modifiable factors to be identified and addressed. Significant resources are required to manage paediatric difficult asthma optimally and only specialist centres should be tasked with the assessment of these patients. Although this may have an impact on healthcare resources, long term benefits for lung health are significant. Expert commentary: The management of paediatric difficult asthma is not simple and involves numerous professionals with varied expertise. However, if it is not undertaken with the appropriate skills, there is a significant risk of children receiving inappropriate invasive investigations and therapies that will have no impact on morbidity.
难治性哮喘患儿尽管接受了高剂量维持治疗,但仍有显著的发病率且无法实现哮喘控制。如果在确诊后病情仍控制不佳,则需要对哮喘难以控制的原因进行详细评估。包括不遵医嘱用药、持续的环境暴露引发哮喘症状以及心理社会因素等潜在的可改变因素导致了这些患者的控制不佳。
本综述的重点是提供一种诊断和管理难治性哮喘的实用方法,包括对长期评估的概述,以确定是否有可能进展为真正的重度哮喘。多学科团队对于识别和解决可改变因素至关重要。最佳管理儿童难治性哮喘需要大量资源,并且只有专科中心才应负责对这些患者进行评估。尽管这可能会对医疗资源产生影响,但对肺部健康的长期益处是显著的。专家评论:儿童难治性哮喘的管理并不简单,涉及众多具有不同专业知识的专业人员。然而,如果没有以适当的技能进行管理,儿童接受不适当的侵入性检查和治疗的风险很大,而这些检查和治疗对发病率并无影响。