血清和胆汁中胆管癌潜在的诊断和预后生物标志物。

Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile.

作者信息

Wang Bin, Chen Liang, Chang Hao-Teng

机构信息

Department of Hepatobiliary Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, China.

Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan.

出版信息

Biomark Med. 2016 Jun;10(6):613-9. doi: 10.2217/bmm-2015-0062. Epub 2016 May 27.

DOI:10.2217/bmm-2015-0062

PMID:27232281

Abstract

Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.

摘要

胆管癌（CCA）是一种极具破坏性的恶性肿瘤，由于其对传统疗法不敏感且无法检测早期肿瘤形成，因而难以治疗。新型分子技术已使得血清和胆汁标志物可用于CCA的诊断和预后评估。在此，我们总结CCA血清和胆汁标志物的主要特征。诸如白细胞介素-6、基质金属蛋白酶、血清素（5-羟色胺）和胆汁酸等生物标志物已显示出改善CCA诊断的前景。最近有几种标志物如细胞角蛋白19片段（CYFRA 21-1）、MK-1和C反应蛋白被证明对CCA预后评估有效。