胸腺上皮细胞中的mTORC2控制胸腺细胞生成和T细胞发育。
mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.
作者信息
Wang Hong-Xia, Cheng Joyce S, Chu Shuai, Qiu Yu-Rong, Zhong Xiao-Ping
机构信息
Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China; Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710;
Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710; Pre-Med (BS/MD) Health Scholar Program, Temple University, Philadelphia, PA 19222;
出版信息
J Immunol. 2016 Jul 1;197(1):141-50. doi: 10.4049/jimmunol.1502698. Epub 2016 May 27.
Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that control TEC development and function are still not well defined. The mammalian or mechanistic target of rapamycin complex (mTORC)2 signals to regulate cell survival, nutrient uptake, and metabolism. We report in the present study that mice with TEC-specific ablation of Rictor, a critical and unique adaptor molecule in mTORC2, display thymic atrophy, which accompanies decreased TEC numbers in the medulla. Moreover, generation of multiple T cell lineages, including conventional TCRαβ T cells, regulatory T cells, invariant NKT cells, and TCRγδ T cells, was reduced in TEC-specific Rictor-deficient mice. Our data demonstrate that mTORC2 in TECs is important for normal thymopoiesis and efficient T cell generation.
胸腺上皮细胞（TECs）在T细胞生成过程中发挥着重要作用。控制TEC发育和功能的机制仍未完全明确。哺乳动物雷帕霉素靶蛋白复合物（mTORC）2发出信号来调节细胞存活、营养摄取和代谢。我们在本研究中报告，特异性敲除Rictor（mTORC2中一个关键且独特的衔接分子）的TEC小鼠表现出胸腺萎缩，同时伴有髓质中TEC数量减少。此外，在TEC特异性Rictor缺陷小鼠中，包括传统TCRαβ T细胞、调节性T细胞、不变自然杀伤T细胞和TCRγδ T细胞在内的多种T细胞谱系的生成均减少。我们的数据表明，TEC中的mTORC2对正常胸腺生成和高效T细胞生成至关重要。
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