肾移植后维生素D水平和甲状旁腺激素的序贯变化

Sequential Changes of Vitamin D Level and Parathyroid Hormone After Kidney Transplantation.

作者信息

Lee H H, Kim A J, Ro H, Jung J Y, Chang J H, Chung W, Park Y H

机构信息

Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea.

出版信息

Transplant Proc. 2016 Apr;48(3):897-9. doi: 10.1016/j.transproceed.2015.12.120.

DOI:10.1016/j.transproceed.2015.12.120

PMID:27234762

Abstract

BACKGROUND

Numerous studies have shown that vitamin D deficiency is common in end stage renal disease patients. However, change of the vitamin D deficiency after kidney transplantation is not fully understood.

METHODS

Twenty-five kidney transplant (KT) recipients with serum 25-hydroxyvitamin D (25D) level, 1,25-dihydroxyvitamin D (1,25D) level, parathyroid hormone (PTH) level before and 6, 12, and 24 months after transplantation were reviewed.

RESULTS

Serum PTH level and 1,25D level showed significant changes at 6 months after transplantation, but did not show further change at 12 months. 25D level did not increase within 6 months after transplantation. However, 25D level showed gradual increase after 6 months. The proportion of recipients with 25D deficiency (<10 ng/mL) was 68%, 40%, and 28% before, 12 months after, and 24 months after transplantation, respectively. Patients with vitamin D deficiency at 24 month were younger at transplantation (37.7 ± 9.6 y vs 48.2 ± 8.0 y; P = .029) and had lower 25D level before transplantation (7.96 ± 1.74 ng/mL vs 10.59 ± 4.35 ng/mL; P = .041).

CONCLUSIONS

25D deficiency is persistent in almost kidney transplant recipients even 12 months after transplantation, although serum PTH levels decrease and serum 25D levels increase after transplantation.

摘要

背景

大量研究表明，维生素D缺乏在终末期肾病患者中很常见。然而，肾移植后维生素D缺乏的变化尚未完全明确。

方法

回顾了25例肾移植（KT）受者移植前及移植后6、12和24个月时的血清25-羟维生素D（25D）水平、1,25-二羟维生素D（1,25D）水平、甲状旁腺激素（PTH）水平。

结果

血清PTH水平和1,25D水平在移植后6个月有显著变化，但在12个月时未显示进一步变化。25D水平在移植后6个月内未升高。然而，25D水平在6个月后呈逐渐升高趋势。25D缺乏（<10 ng/mL）的受者比例在移植前、移植后12个月和移植后24个月分别为68%、40%和28%。移植后24个月维生素D缺乏的患者移植时年龄较小（37.7±9.6岁对48.2±8.0岁；P = 0.029），移植前25D水平较低（7.96±1.74 ng/mL对10.59±4.35 ng/mL；P = 0.041）。