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小儿使用小口径牛颈静脉导管(Contegra)进行右心室流出道重建的早期临床结果。

Early clinical outcomes of right ventricular outflow tract reconstruction with small caliber bovine jugular vein conduit (Contegra) in small children.

作者信息

Kido Takashi, Hoashi Takaya, Kagisaki Koji, Fujiyoshi Toshiki, Kitano Masataka, Kurosaki Kenichi, Shiraishi Isao, Yagihara Toshikatsu, Sawa Yoshiki, Ichikawa Hajime

机构信息

Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, 5-7-1, Fujishirodai, Suita, 565-8565, Osaka, Japan.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

出版信息

J Artif Organs. 2016 Dec;19(4):364-371. doi: 10.1007/s10047-016-0908-7. Epub 2016 May 28.

Abstract

This study reviewed early clinical outcomes of right ventricular outflow tract reconstruction with Contegra valved conduits in pediatric patients. Between April 2013 and July 2014, thirteen pediatric patients underwent right ventricular outflow tract reconstruction with Contegra valved conduits. The size of the implanted conduits were 12 mm in 5 patients, 14 mm in 3, 16 mm in 3, and then 2 patients were implanted with bicuspidized conduits for downsizing the conduit to 9 and 10 mm in each. Follow-ups were completed in all patients. One conduit was explanted 7 days after a neonatal biventricular repair for Ebstein's anomaly and pulmonary atresia, timed to be at the point of conversion to a single ventricular palliation. Among the 5 patients who developed significant pulmonary insufficiency and/or conduit stenosis, 3 patients exhibited persistent pulmonary hypertension. Both the bicuspidized conduits resulted in early pulmonary insufficiency. One patient implanted with a ring-supported conduit developed coronary artery stenosis, caused by suppression between the ring of the implanted conduit and the annulus of the mechanical vale. Although the small caliber Contegra valved conduit might be an alternative to RVOT reconstruction, the indication should be carefully considered. More than mild pulmonary hypertension, and low body weight at operation of less than 3.0 kg caused early conduit dysfunction.

摘要

本研究回顾了小儿患者使用康蒂格拉带瓣管道进行右心室流出道重建的早期临床结果。2013年4月至2014年7月期间,13例小儿患者使用康蒂格拉带瓣管道进行了右心室流出道重建。植入管道的尺寸为:5例患者为12毫米,3例为14毫米,3例为16毫米,另有2例植入双叶化管道以将管道尺寸缩小至9毫米和10毫米。所有患者均完成随访。1例新生儿双心室修复治疗埃布斯坦畸形和肺动脉闭锁后7天,因计划转换为单心室姑息治疗而取出1根管道。在5例出现严重肺动脉瓣关闭不全和/或管道狭窄的患者中,3例表现为持续性肺动脉高压。两根双叶化管道均导致早期肺动脉瓣关闭不全。1例植入带环支撑管道的患者出现冠状动脉狭窄,原因是植入管道的环与机械瓣膜瓣环之间的压迫。尽管小口径康蒂格拉带瓣管道可能是右心室流出道重建的一种替代选择,但应仔细考虑其适应证。超过轻度的肺动脉高压以及手术时体重低于3.0千克会导致早期管道功能障碍。

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