Stücker Markus, Debus Eike Sebastian, Hoffmann Johannes, Jünger Michael, Kröger Knut, Mumme Achim, Ramelet Albert-Adrien, Rabe Eberhard
Department of Dermatology and Allergology, and Center for Venous Disorders of the Departments of Dermatology and Vascular Surgery, Ruhr University Bochum, Bochum, Germany.
Department of Vascular Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
J Dtsch Dermatol Ges. 2016 Jun;14(6):575-83. doi: 10.1111/ddg.13006.
Chronic venous diseases are very common. Early symptoms such as a sensation of swelling and heaviness may occur without objectifiable findings, but are nevertheless perceived as bothersome. Progressive disease - marked by varicose veins and symptoms of chronic venous insufficiency - is associated with considerable impairment in quality of life.
The present consensus recommendations are based on publications in Pubmed-listed journals as well as relevant international therapeutic guidelines on chronic venous diseases. Only conclusive randomized controlled trials (RCTs) and review articles/meta-analyses were included.
Symptom-based treatment of chronic venous diseases is based on three therapeutic pillars with proven efficacy: invasive therapy, compression therapy, and oral pharmacological treatment. According to current therapeutic guidelines, invasive procedures aimed at restoring unimpaired venous blood flow as well as improving or eliminating pathological changes should be the first-line approach. If an invasive approach is infeasible or undesirable, or if symptoms persist following a therapeutic intervention, optimal use of symptom-based treatment options is recommended. Compression and pharmacological therapy may each be used as sole treatment or in combination. To guarantee maximum therapeutic success, individual treatment decisions should be made on a case-by-case basis.
Chronic venous diseases should be treated on the basis of individual pathophysiological disturbances. Symptom-based treatment of chronic venous disorders encompasses invasive therapy, compression therapy, and oral pharmacological therapy. Considerations in choosing the appropriate treatment option should include both objective signs as well as subjective symptoms.
慢性静脉疾病非常常见。早期症状如肿胀和沉重感可能在无客观体征的情况下出现,但仍会被视为令人烦恼。以静脉曲张和慢性静脉功能不全症状为特征的进展性疾病与生活质量的显著受损相关。
本共识性建议基于发表在PubMed收录期刊上的文献以及关于慢性静脉疾病的相关国际治疗指南。仅纳入了确凿的随机对照试验(RCT)以及综述文章/荟萃分析。
慢性静脉疾病基于症状的治疗基于三个已证实有效的治疗支柱:侵入性治疗、压迫治疗和口服药物治疗。根据当前治疗指南,旨在恢复未受损静脉血流以及改善或消除病理变化的侵入性手术应作为一线方法。如果侵入性方法不可行或不可取,或者如果在治疗干预后症状持续存在,则建议最佳使用基于症状的治疗方案。压迫治疗和药物治疗均可单独使用或联合使用。为确保最大治疗成功,应根据具体情况做出个体化治疗决策。
慢性静脉疾病应根据个体病理生理紊乱进行治疗。慢性静脉疾病基于症状的治疗包括侵入性治疗、压迫治疗和口服药物治疗。选择合适治疗方案时的考虑因素应包括客观体征和主观症状。