医疗保健数据库中慢性阻塞性肺疾病（COPD）诊断的验证：一项系统评价方案。

Validation of chronic obstructive pulmonary disease (COPD) diagnoses in healthcare databases: a systematic review protocol.

作者信息

Rimland Joseph M, Abraha Iosief, Luchetta Maria Laura, Cozzolino Francesco, Orso Massimiliano, Cherubini Antonio, Dell'Aquila Giuseppina, Chiatti Carlos, Ambrosio Giuseppe, Montedori Alessandro

机构信息

Geriatrics and Geriatric Emergency Care, Italian National Research Center on Aging, Ancona, Italy.

Health Planning Service, Regional Health Authority of Umbria, Perugia, Italy.

出版信息

BMJ Open. 2016 Jun 1;6(6):e011777. doi: 10.1136/bmjopen-2016-011777.

DOI:10.1136/bmjopen-2016-011777

PMID:27251687

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4893853/

Abstract

INTRODUCTION

Healthcare databases are useful sources to investigate the epidemiology of chronic obstructive pulmonary disease (COPD), to assess longitudinal outcomes in patients with COPD, and to develop disease management strategies. However, in order to constitute a reliable source for research, healthcare databases need to be validated. The aim of this protocol is to perform the first systematic review of studies reporting the validation of codes related to COPD diagnoses in healthcare databases.

METHODS AND ANALYSIS

MEDLINE, EMBASE, Web of Science and the Cochrane Library databases will be searched using appropriate search strategies. Studies that evaluated the validity of COPD codes (such as the International Classification of Diseases 9th Revision and 10th Revision system; the Real codes system or the International Classification of Primary Care) in healthcare databases will be included. Inclusion criteria will be: (1) the presence of a reference standard case definition for COPD; (2) the presence of at least one test measure (eg, sensitivity, positive predictive values, etc); and (3) the use of a healthcare database (including administrative claims databases, electronic healthcare databases or COPD registries) as a data source. Pairs of reviewers will independently abstract data using standardised forms and will assess quality using a checklist based on the Standards for Reporting of Diagnostic accuracy (STARD) criteria. This systematic review protocol has been produced in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) 2015 statement.

ETHICS AND DISSEMINATION

Ethics approval is not required. Results of this study will be submitted to a peer-reviewed journal for publication. The results from this systematic review will be used for outcome research on COPD and will serve as a guide to identify appropriate case definitions of COPD, and reference standards, for researchers involved in validating healthcare databases.

TRIAL REGISTRATION NUMBER

CRD42015029204.

摘要

引言

医疗保健数据库是调查慢性阻塞性肺疾病（COPD）流行病学、评估COPD患者纵向结局以及制定疾病管理策略的有用资源。然而，为了成为可靠的研究来源，医疗保健数据库需要进行验证。本方案的目的是对报告医疗保健数据库中与COPD诊断相关代码验证的研究进行首次系统评价。

方法与分析

将使用适当的检索策略检索MEDLINE、EMBASE、科学网和考克兰图书馆数据库。纳入评估医疗保健数据库中COPD代码（如国际疾病分类第9版和第10版系统、真实代码系统或基层医疗国际分类）有效性的研究。纳入标准将包括：（1）存在COPD的参考标准病例定义；（2）存在至少一种测试指标（如敏感性、阳性预测值等）；以及（3）使用医疗保健数据库（包括行政索赔数据库、电子医疗保健数据库或COPD登记册）作为数据源。成对的评审员将使用标准化表格独立提取数据，并将根据基于诊断准确性报告标准（STARD）标准的清单评估质量。本系统评价方案已根据系统评价和Meta分析方案的首选报告项目（PRISMA-P）2015声明制定。