维生素B6拮抗剂诱发癫痫发作时c-Fos信使核糖核酸的诱导作用

c-Fos mRNA induction under vitamin B6 antagonist-induced seizure.

作者信息

Mizuno A, Mizobuchi T, Ishibashi Y, Matsuda M

机构信息

Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan.

出版信息

Neurosci Lett. 1989 Apr 10;98(3):272-5. doi: 10.1016/0304-3940(89)90412-6.

DOI:10.1016/0304-3940(89)90412-6

PMID:2725947

Abstract

c-Fos mRNA expression was studied in mouse brain after vitamin B6 antagonist-induced seizure. The vitamin B6 antagonists used were hydrazine, thiosemicarbazide, penicillamine and deoxypyridoxine. Only deoxypyridoxine was effective in increasing c-fos mRNA and c-fos protein expression in nerve cells. The other 3 antagonists had levels of c-fos mRNA below or equal to basal level. The seizure activity induced by several vitamin B6 antagonists resulted in different effects on c-fos gene expression.

摘要

在维生素B6拮抗剂诱发癫痫发作后，对小鼠大脑中的c-Fos信使核糖核酸（mRNA）表达进行了研究。所使用的维生素B6拮抗剂有肼、氨基硫脲、青霉胺和脱氧吡哆醇。只有脱氧吡哆醇能有效增加神经细胞中c-fos mRNA和c-fos蛋白的表达。其他3种拮抗剂的c-fos mRNA水平低于或等于基础水平。几种维生素B6拮抗剂诱发的癫痫活动对c-fos基因表达产生了不同影响。