Kotsakis Afrothite, Stevens Derek, Frndova Helena, Neal Richard, Williamson Grace, Mohseni-Bod Hadi, Parshuram Christopher S
1Department of Critical Care Medicine, Hospital for Sick Children, Toronto, ON, Canada. 2Department of Pediatrics, University of Toronto, ON, Canada. 3Clinical Research Service, Hospital for Sick Children, Toronto, ON, Canada. 4Pediatric Intensive Care, Birmingham Children's Hospital, Birmingham, United Kingdom. 5Pediatric Intensive Care, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.
Pediatr Crit Care Med. 2016 Jun;17(6):558-62. doi: 10.1097/PCC.0000000000000735.
ICU readmission within 48 hours of discharge is associated with increased mortality. The objectives of this study were to describe the frequency of, factors associated with, and outcomes associated with unplanned PICU readmission.
A retrospective case-control study was performed. We evaluated 13 candidate risk factors and report patient outcomes following readmission. Subgroup analyses were performed for patients discharged from the cardiac PICU and medical-surgical PICU.
The study was undertaken at the Hospital for Sick Children, Department of Critical Care Medicine.
Eligible patients were discharged from the PICU to an inpatient ward between December 2006 and January 2013. Case patients were readmitted to the PICU within 48 hours of discharge.
There were 10,422 eligible patient discharges; 264 (2.5%) were readmitted within 48 hours. In the univariable analysis, unplanned readmission was associated with PICU patient admissions of younger age, lower weight, greater duration of PICU stay, greater cumulative stay in PICU in the past 2 years, higher Pediatric Logistic Organ Dysfunction score on PICU discharge, discharge outside goal discharge time (06:00-11:59 hr), use of extracorporeal organ support during ICU stay, greater Bedside Pediatric Early Warning Score, at discharge and discharge from the cardiac PICU. In the multivariable analysis, the factors most significantly associated with unplanned PICU readmission were length of stay more than 48 hours, greater cumulative length of PICU stay in the past 2 years, discharge from cardiac PICU, and higher Pediatric Logistic Organ Dysfunction and Bedside Pediatric Early Warning Scores on index discharge. Mortality was 1.8 times (p = 0.03) higher in patients with an unplanned PICU readmission compared with patients during their index PICU admission.
The only potentially modifiable factors we found associated with PICU readmission within 48 hours of discharge were discharge time of day and the Pediatric Logistic Organ Dysfunction and Bedside Pediatric Early Warning Scores at the time of PICU discharge.
出院后48小时内再次入住重症监护病房(ICU)与死亡率增加相关。本研究的目的是描述非计划入住儿科重症监护病房(PICU)的频率、相关因素及预后。
进行了一项回顾性病例对照研究。我们评估了13个候选风险因素,并报告再次入院后的患者预后。对从心脏PICU和内科-外科PICU出院的患者进行了亚组分析。
该研究在病童医院重症医学科进行。
符合条件的患者于2006年12月至2013年1月期间从PICU出院至住院病房。病例患者在出院后48小时内再次入住PICU。
共有10422例符合条件的患者出院;264例(2.5%)在48小时内再次入院。在单变量分析中,非计划再次入院与年龄较小、体重较低、PICU住院时间较长、过去2年内在PICU累计住院时间较长、PICU出院时儿科逻辑器官功能障碍评分较高、出院时间超出目标出院时间(06:00 - 11:59时)、ICU住院期间使用体外器官支持、出院时及从心脏PICU出院时床边儿科早期预警评分较高有关。在多变量分析中,与非计划入住PICU最显著相关的因素是住院时间超过48小时、过去2年内在PICU累计住院时间较长、从心脏PICU出院、以及首次出院时儿科逻辑器官功能障碍和床边儿科早期预警评分较高。与首次入住PICU期间的患者相比,非计划入住PICU的患者死亡率高1.8倍(p = 0.03)。
我们发现与出院后48小时内入住PICU相关的唯一潜在可改变因素是一天中的出院时间以及PICU出院时的儿科逻辑器官功能障碍和床边儿科早期预警评分。