Buttenschøn Henrietta Nørmølle, Krogh Jesper, Nielsen Marit Nyholm, Kaerlev Linda, Nordentoft Merete, Mors Ole
1Translational Neuropsychiatry Unit,Department of Clinical Medicine,Aarhus University,Risskov,Denmark.
3Mental Health Center Copenhagen,Mental Health Services in Capital Region,University of Copenhagen,Copenhagen,Denmark.
Acta Neuropsychiatr. 2017 Feb;29(1):59-64. doi: 10.1017/neu.2016.26. Epub 2016 Jun 6.
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in depression. The aim was to investigate the potential association between depression and seven genes regulating or interfering with the HPA axis, including the gene encoding angiotensin converting enzyme (ACE).
In total, 78 single nucleotide polymorphisms (SNPs) and one insertion/deletion polymorphism were genotyped. The study included 408 individuals with depression and 289 controls. In a subset of cases, the interaction between genetic variants and stressful life events (SLEs) was investigated.
After quality control, 68 genetic variants were left for analyses. Four of nine variants within ACE were nominally associated with depression and a gene-wise association was likewise observed. However, none of the SNPs located within AVP, CRH, CRHR1, CRHR2, FKBP5 or NC3C1 were associated with depression. One nominally significant interaction, most likely due to chance, was identified.
The results indicate that ACE could be a potential candidate gene for depression.
据报道，抑郁症患者存在下丘脑 - 垂体 - 肾上腺（HPA）轴功能失调。本研究旨在探讨抑郁症与七个调节或干扰HPA轴的基因之间的潜在关联，其中包括编码血管紧张素转换酶（ACE）的基因。
总共对78个单核苷酸多态性（SNP）和1个插入/缺失多态性进行基因分型。该研究纳入了408名抑郁症患者和289名对照。在部分病例中，研究了基因变异与应激性生活事件（SLE）之间的相互作用。
质量控制后，留下68个基因变异进行分析。ACE基因内九个变异中的四个与抑郁症存在名义上的关联，同样观察到基因水平的关联。然而，AVP、CRH、CRHR1、CRHR2、FKBP5或NC3C1基因内的SNP均与抑郁症无关联。确定了一个名义上显著的相互作用，很可能是偶然因素导致。
结果表明，ACE可能是抑郁症的一个潜在候选基因。
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