Sarinnapakorn Veerasak, Sunthorntepwarakul Thongkum, Deerochanawong Chaicharn, Niramitmahapanya Sathit, Napartivaumnuay Navapom
J Med Assoc Thai. 2016 Feb;99 Suppl 2:S99-105.
Diabetic foot ulcers are a major cause of non-traumatic lower limb amputation in patients with type 2 diabetes. In 2014, the Diabetes Association of Thailand issued new guidelines for classifying type 2 diabetes patients' levels of risk of developing foot ulcers, but no research on the prevalence of type 2 diabetes using these new classification criteria had been performed prior to the current study.
To study the prevalence of diabetic foot ulcers overall and in different risk groups in type 2 diabetes mellitus patients in Rajavithi Hospital, and to evaluate risk factors of these groups and correlations with ankle brachial index (ABI) and cardio-ankle vascular index (CAVI).
593 type 2 diabetes patients at Rajavithi Hospital were studied and classified into risk groups based on the classification criteria issued by the Thailand Diabetes Association in 2014. ABI measurements were taken from 132 patients, and measurements of CAVI were taken from 101 patients.
The prevalence of foot ulcers was 3.4% and 2.2% of patients had a history of amputation. The percentages of patients at low, intermediate and high risk of developing foot ulcers were 55.8%, 33.6% and 10.6%, respectively. Age, duration of diabetes, estimated glomerular filtration rate (eGFR), history of hypertension, dyslipidemia, nephropathy, cardiovascular disease (CVA), deformity of foot, numbness, abnormal protective sensation, pulse deficit, ulcer, and amputation were factors significantly associated with a high risk of foot ulcers (p < 0.05), but fasting plasma glucose (FPG) and HbA1c were not significant factors. There was an association between cerebrovascular accident and abnormal ABI.
Nearly half of these type 2 diabetes patients were in the groups with an intermediate or high risk of developing foot ulcers. Screening of patients at risk of foot ulceration is necessary in order to classify patients into risk groups and provide appropriate education, as well as proper monitoring and management.
糖尿病足溃疡是2型糖尿病患者非创伤性下肢截肢的主要原因。2014年,泰国糖尿病协会发布了2型糖尿病患者足部溃疡发生风险水平的新分类指南,但在本研究之前,尚未有使用这些新分类标准对2型糖尿病患病率进行的研究。
研究拉贾维提医院2型糖尿病患者中糖尿病足溃疡的总体患病率及不同风险组的患病率,并评估这些组的风险因素以及与踝肱指数(ABI)和心踝血管指数(CAVI)的相关性。
对拉贾维提医院的593例2型糖尿病患者进行研究,并根据泰国糖尿病协会2014年发布的分类标准将其分为风险组。对132例患者进行了ABI测量,对101例患者进行了CAVI测量。
足部溃疡的患病率为3.4%,有截肢史的患者占2.2%。发生足部溃疡低、中、高风险患者的百分比分别为55.8%、33.6%和10.6%。年龄、糖尿病病程、估计肾小球滤过率(eGFR)、高血压病史、血脂异常、肾病、心血管疾病(CVA)、足部畸形、麻木、保护性感觉异常、脉搏缺损、溃疡和截肢是与足部溃疡高风险显著相关的因素(p<0.05),但空腹血糖(FPG)和糖化血红蛋白(HbA1c)不是显著因素。脑血管意外与ABI异常之间存在关联。
这些2型糖尿病患者中近一半属于发生足部溃疡中、高风险组。有必要对足部溃疡风险患者进行筛查,以便将患者分类到风险组,并提供适当的教育以及恰当的监测和管理。